ArticleEnzyme research2011
Autotaxin: its role in biology of melanoma cells and as a pharmacological target.
Article in Enzyme research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 26 citations in OpenAlex.
- Lipidomics in Melanoma: Insights into Disease Progression and Therapeutical Targets.International journal of molecular sciences · 2026Review
- A novel strategy for sorafenib-resistant hepatocellular carcinoma: autotaxin Inhibition by PF-8380.Journal of cancer research and clinical oncology · 2025Article
- A vascularizedMaterials today. Bio · 2024Article
- Article
- Enpp2 Expression by Dendritic Cells Is a Key Regulator in Migration.Biomedicines · 2021Article
- LSD1 and Aberrant DNA Methylation Mediate Persistence of Enteroendocrine Progenitors That SupportCancer research · 2021Article
- Cholestasis-Associated Pruritus and Its Pruritogens.Frontiers in medicine · 2021Review
- Lipid metabolic Reprogramming: Role in Melanoma Progression and Therapeutic Perspectives.Cancers · 2020Review
- Autotaxin upregulated by STAT3 activation contributes to invasion in pancreatic neuroendocrine neoplasms.Endocrine connections · 2018Article
- Serum Autotaxin is a Marker of the Severity of Liver Injury and Overall Survival in Patients with Cholestatic Liver Diseases.Scientific reports · 2016Article
- c-Jun promotes cell migration and drives expression of the motility factor ENPP2 in soft tissue sarcomas.The Journal of pathology · 2014Article
- Meeting the challenge of ascites in ovarian cancer: new avenues for therapy and research.Nature reviews. Cancer · 2013Article
- Galectin-3 contributes to melanoma growth and metastasis via regulation of NFAT1 and autotaxin.Cancer research · 2012Article
- Activation of the P2Y1 receptor induces apoptosis and inhibits proliferation of prostate cancer cells.Biochemical pharmacology · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Autotaxin (ATX) is an extracellular lysophospholipase D (lysoPLD) released from normal cells and cancer cells. Activity of ATX is detected in various biological fluids. The lysophosphatidic acid (LPA) is the main product of ATX. LPA acting through specific G protein-coupled receptors (LPA(1)-LPA(6)) affects immunological response, normal development, and malignant tumors' formation and progression. In this review, the impact of autotoxin on biology of melanoma cells and potential treatment is discussed.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.