ArticlePloS one2011
Identifying a window of vulnerability during fetal development in a maternal iron restriction model.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 55 citations in OpenAlex.
- The Critical Role of Iron in Pregnancy, Puerperium, and Fetal Development.Journal of clinical medicine · 2025Review
- Normalization of Fetal Cerebral and Hepatic Iron by Parental Iron Therapy to Pregnant Rats with Systemic Iron Deficiency without Anemia.Nutrients · 2024Article
- Article
- Brain Iron Metabolism, Redox Balance and Neurological Diseases.Antioxidants (Basel, Switzerland) · 2023Review
- Association of Prenatal Maternal Anemia with Tics and Tourette's Syndrome in Offspring.Journal of personalized medicine · 2021Article
- Effects and Reversibility of Pre- and Post-natal Iron and Omega-3 Fatty Acid Deficiency, Alone and in Combination, on Bone Development in Rats.Frontiers in nutrition · 2021Article
- Maternal Iron Deficiency Programs Offspring Cognition and Its Relationship with Gastrointestinal Microbiota and Metabolites.International journal of environmental research and public health · 2020Article
- Impairment of the Developing Human Brain in Iron Deficiency: Correlations to Findings in Experimental Animals and Prospects for Early Intervention Therapy.Pharmaceuticals (Basel, Switzerland) · 2019Review
- Iron deficiency disrupts embryonic haematopoiesis but not the endothelial to haematopoietic transition.Scientific reports · 2019Article
- The Impact of Traditional Food and Lifestyle Behavior on Epigenetic Burden of Chronic Disease.Global challenges (Hoboken, NJ) · 2017Review
- Modest and Severe Maternal Iron Deficiency in Pregnancy are Associated with Fetal Anaemia and Organ-Specific Hypoxia in Rats.Scientific reports · 2017Article
- Maternal micronutrient consumption periconceptionally and during pregnancy: a prospective cohort study.Public health nutrition · 2017Article
- The placenta: the forgotten essential organ of iron transport.Nutrition reviews · 2016Review
- Mild Maternal Iron Deficiency Anemia Induces Hearing Impairment Associated with Reduction of Ribbon Synapse Density and Dysregulation of VGLUT3, Myosin VIIa, and Prestin Expression in Young Guinea Pigs.Neurotoxicity research · 2016Article
- Perspectives on the design and methodology of periconceptional nutrient supplementation trials.Trials · 2016Article
- Prevalence of anemia and associations between neonatal iron status, hepcidin, and maternal iron status among neonates born to pregnant adolescents.Pediatric research · 2016Article
- Expression and cellular localization of hepcidin mRNA and protein in normal rat brain.BMC neuroscience · 2015Article
- Fetal iron deficiency and genotype influence emotionality in infant rhesus monkeys.The Journal of nutrition · 2015Article
- Gestational iron deficiency differentially alters the structure and function of white and gray matter brain regions of developing rats.The Journal of nutrition · 2014Article
- Iron deficiency with or without anemia impairs prepulse inhibition of the startle reflex.Hippocampus · 2013Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
It is well acknowledged from observations in humans that iron deficiency during pregnancy can be associated with a number of developmental problems in the newborn and developing child. Due to the obvious limitations of human studies, the stage during gestation at which maternal iron deficiency causes an apparent impairment in the offspring remains elusive. In order to begin to understand the time window(s) during pregnancy that is/are especially susceptible to suboptimal iron levels, which may result in negative effects on the development of the fetus, we developed a rat model in which we were able to manipulate and monitor the dietary iron intake during specific stages of pregnancy and analyzed the developing fetuses. We established four different dietary-feeding protocols that were designed to render the fetuses iron deficient at different gestational stages. Based on a functional analysis that employed Auditory Brainstem Response measurements, we found that maternal iron restriction initiated prior to conception and during the first trimester were associated with profound changes in the developing fetus compared to iron restriction initiated later in pregnancy. We also showed that the presence of iron deficiency anemia, low body weight, and changes in core body temperature were not defining factors in the establishment of neural impairment in the rodent offspring.Our data may have significant relevance for understanding the impact of suboptimal iron levels during pregnancy not only on the mother but also on the developing fetus and hence might lead to a more informed timing of iron supplementation during pregnancy.
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