ArticlePloS one2011
Epistatic association mapping in homozygous crop cultivars.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 55 citations in OpenAlex.
- BLUPmrMLM: A Fast mrMLM Algorithm in Genome-wide Association Studies.Genomics, proteomics & bioinformatics · 2024Article
- Identification of QTNs, QTN-by-environment interactions, and their candidate genes for salt tolerance related traits in soybean.BMC plant biology · 2024Article
- GWAS for main effects and epistatic interactions for grain morphology traits in wheat.Physiology and molecular biology of plants : an international journal of functional plant biology · 2022Article
- Analysis of genotype × environment interactions for agronomic traits of soybean (Frontiers in genetics · 2022Article
- Identification of quantitative trait loci (QTLs) and candidate genes for seed shape and 100-seed weight in soybean [Frontiers in plant science · 2022Article
- Identification of genetic variation for salt tolerance in Brassica napus using genome-wide association mapping.Molecular genetics and genomics : MGG · 2021Article
- High-Resolution Mapping in Two RIL Populations Refines Major "QTL Hotspot" Regions for Seed Size and Shape in Soybean (International journal of molecular sciences · 2020Article
- A Multi-Locus Association Model Framework for Nested Association Mapping With Discriminating QTL Effects in Various Subpopulations.Frontiers in genetics · 2020Article
- Article
- Methodological implementation of mixed linear models in multi-locus genome-wide association studies.Briefings in bioinformatics · 2018Article
- Dissection of complicate genetic architecture and breeding perspective of cottonseed traits by genome-wide association study.BMC genomics · 2018Article
- Earliness traits in rapeseed (Brassica napus): SNP loci and candidate genes identified by genome-wide association analysis.DNA research : an international journal for rapid publication of reports on genes and genomes · 2018Article
- Capturing pair-wise epistatic effects associated with three agronomic traits in barley.Genetica · 2018Article
- Stable, Environmental Specific and Novel QTL Identification as Well as Genetic Dissection of Fatty Acid Metabolism inFrontiers in plant science · 2018Article
- pLARmEB: integration of least angle regression with empirical Bayes for multilocus genome-wide association studies.Heredity · 2017Article
- Iterative sure independence screening EM-Bayesian LASSO algorithm for multi-locus genome-wide association studies.PLoS computational biology · 2017Article
- Bioinformatics Approach in Plant Genomic Research.Current genomics · 2016Article
- Mapping small-effect and linked quantitative trait loci for complex traits in backcross or DH populations via a multi-locus GWAS methodology.Scientific reports · 2016Article
- EcoTILLING revealed SNPs in GhSus genes that are associated with fiber- and seed-related traits in upland cotton.Scientific reports · 2016Article
- Identification of QTLs with main, epistatic and QTL by environment interaction effects for seed shape and hundred-seed weight in soybean across multiple years.Journal of genetics · 2016Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The genetic dissection of complex traits plays a crucial role in crop breeding. However, genetic analysis and crop breeding have heretofore been performed separately. In this study, we designed a new approach that integrates epistatic association analysis in crop cultivars with breeding by design. First, we proposed an epistatic association mapping (EAM) approach in homozygous crop cultivars. The phenotypic values of complex traits, along with molecular marker information, were used to perform EAM. In our EAM, all the main-effect quantitative trait loci (QTLs), environmental effects, QTL-by-environment interactions and QTL-by-QTL interactions were included in a full model and estimated by empirical Bayes approach. A series of Monte Carlo simulations was performed to confirm the reliability of the new method. Next, the information from all detected QTLs was used to mine novel alleles for each locus and to design elite cross combination. Finally, the new approach was adopted to dissect the genetic basis of seed length in 215 soybean cultivars obtained, by stratified random sampling, from 6 geographic ecotypes in China. As a result, 19 main-effect QTLs and 3 epistatic QTLs were identified, more than 10 novel alleles were mined and 3 elite parental combinations, such as Daqingdou and Zhengzhou790034, were predicted.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.