ArticleInternational journal of Alzheimer's disease2011
May "mitochondrial eve" and mitochondrial haplogroups play a role in neurodegeneration and Alzheimer's disease?
Article in International journal of Alzheimer's disease, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 25 citations in OpenAlex.
- Mitochondrial DNA oxidative mutations are elevated in Mexican American women potentially implicating Alzheimer's disease.npj aging · 2022Article
- Mitochondrial DNA and Alzheimer's disease: a first case-control study of the Tunisian population.Molecular biology reports · 2022Article
- Investigating the importance of individual mitochondrial genotype in susceptibility to drug-induced toxicity.Biochemical Society transactions · 2020Review
- Feasibility of cellular bioenergetics as a biomarker in porphyria patients.Molecular genetics and metabolism reports · 2019Article
- Cellular Abnormalities and Emerging Biomarkers in Alcohol-Associated Liver Disease.Gene expression · 2018Review
- Roles of the mitochondrial genetics in cancer metastasis: not to be ignored any longer.Cancer metastasis reviews · 2018Review
- No effect of mitochondrial genotype on reproductive plasticity following exposure to a non-infectious pathogen challenge in female or male Drosophila.Scientific reports · 2017Article
- Mitochondria, Cybrids, Aging, and Alzheimer's Disease.Progress in molecular biology and translational science · 2017Review
- Absence of Relationship between Mitochondrial DNA Haplogroups and Cisplatin-Induced Hearing Loss.International journal of otolaryngology · 2017Article
- Alzheimer's pathogenesis and its link to the mitochondrion.Oxidative medicine and cellular longevity · 2015Review
- The Alzheimer's disease mitochondrial cascade hypothesis: progress and perspectives.Biochimica et biophysica acta · 2014Review
- Mitochondria and cell bioenergetics: increasingly recognized components and a possible etiologic cause of Alzheimer's disease.Antioxidants & redox signaling · 2012Review
- In vivo quantification reveals extensive natural variation in mitochondrial form and function in Caenorhabditis briggsae.PloS one · 2012Article
- Hypergonadotropic hypogonadism, progressive early-onset spinocerebellar ataxia, and late-onset sensorineural hearing loss: case report and literature review.Balkan journal of medical genetics : BJMG · 2011Article
- Hypoxia in the regulation of neural stem cells.Cellular and molecular life sciences : CMLS · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mitochondria, the powerhouse of the cell, play a critical role in several metabolic processes and apoptotic pathways. Multiple evidences suggest that mitochondria may be crucial in ageing-related neurodegenerative diseases. Moreover, mitochondrial haplogroups have been linked to multiple area of medicine, from normal ageing to diseases, including neurodegeneration. Polymorphisms within the mitochondrial genome might lead to impaired energy generation and to increased amount of reactive oxygen species, having either susceptibility or protective role in several diseases. Here, we highlight the role of the mitochondrial haplogroups in the pathogenetic cascade leading to diseases, with special attention to Alzheimer's disease.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.