ArticleVirchows Archiv. A, Pathological anatomy and histopathology1990
Morphological detection and quantification of lipoprotein(a) deposition in atheromatous lesions of human aorta and coronary arteries.
Article in Virchows Archiv. A, Pathological anatomy and histopathology, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 23 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 93 citations in OpenAlex.
- Genome-Wide Association Study HighlightsArteriosclerosis, thrombosis, and vascular biology · 2021Pooled it
- Lipoprotein(a) as a Risk Factor for Cardiovascular Diseases: Pathophysiology and Treatment Perspectives.International journal of environmental research and public health · 2023Review
- Association between lipoprotein(a) (Lp(a)) levels and Lp(a) genetic variants with coronary artery calcification.BMC medical genetics · 2020Article
- Dysregulated serum lipid profile and its correlation to disease activity in young female adults diagnosed with systemic lupus erythematosus: a cross-sectional study.Lipids in health and disease · 2020Article
- Race-Based Differences in Lipoprotein(a)-Associated Risk of Carotid Atherosclerosis.Arteriosclerosis, thrombosis, and vascular biology · 2019Article
- Lipoprotein (a) as a cause of cardiovascular disease: insights from epidemiology, genetics, and biology.Journal of lipid research · 2016Review
- HyperLp(a)lipoproteinaemia: unmet need of diagnosis and treatment?Blood transfusion = Trasfusione del sangue · 2016Article
- Smooth Muscle Cell Foam Cell Formation, Apolipoproteins, and ABCA1 in Intracranial Aneurysms: Implications for Lipid Accumulation as a Promoter of Aneurysm Wall Rupture.Journal of neuropathology and experimental neurology · 2016Article
- Hypoascorbemia induces atherosclerosis and vascular deposition of lipoprotein(a) in transgenic mice.American journal of cardiovascular disease · 2015Article
- Image analysis tools for evaluation of microscopic views of immunohistochemically stained specimen in medical research-a review.Journal of medical systems · 2012Review
- Abnormal lipoprotein(a) levels predict coronary artery calcification in Southeast Asians but not in Caucasians: use of noninvasive imaging for evaluation of an emerging risk factor.Journal of cardiovascular translational research · 2011Article
- Automation of immunohistochemical evaluation in breast cancer using image analysis.World journal of clinical oncology · 2011Article
- Datamining approach for automation of diagnosis of breast cancer in immunohistochemically stained tissue microarray images.The open medical informatics journal · 2010Article
- Lipoprotein(a) was an independent predictor for major coronary events in treated hypertensive men.Clinical cardiology · 2002Article
- Lipoprotein(a) and coronary heart disease risk.Current cardiology reports · 1999Review
- Preferential influx and decreased fractional loss of lipoprotein(a) in atherosclerotic compared with nonlesioned rabbit aorta.The Journal of clinical investigation · 1996Article
- Apolipoprotein(a) deposition in atherosclerotic plaques of cerebral vessels. A potential role for endothelial cells in lesion formation.The American journal of pathology · 1995Article
- Homocysteine and other sulfhydryl compounds enhance the binding of lipoprotein(a) to fibrin: a potential biochemical link between thrombosis, atherogenesis, and sulfhydryl compound metabolism.Proceedings of the National Academy of Sciences of the United States of America · 1992Article
- Immunohistochemical distribution of lipoprotein epitopes in xanthomata from patients with familial hypercholesterolemia.The American journal of pathology · 1992Article
- Lipoprotein (a) inhibits the generation of transforming growth factor beta: an endogenous inhibitor of smooth muscle cell migration.The Journal of cell biology · 1991Article
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lipoprotein(a), as an atherogenic particle, represents an independent risk factor for coronary heart disease. In the present study the morphological distribution of apoprotein (a) and apoprotein B within the arterial wall is described. Apoprotein B, a constituent of very low-density lipoprotein, low-density lipoprotein and lipoprotein(a) has previously been demonstrated in atheromatous lesions. Lipoprotein(a) possesses an additional protein, designated apoprotein (a). Autopsy material (n = 74) from the left coronary artery and from the thoracic aorta has been examined by means of immunohistochemistry and both apoprotein (a) and apoprotein B were detected, primarily associated with the extracellular matrix and accumulating in lesions in the arterial wall. The staining pattern for both antigens was almost always found to be congruent, suggesting that the detection of (a)-antigen has to be attributed at least in part to the presence of lipoprotein(a). It is concluded that both low-density lipoprotein and lipoprotein(a) have an important role in the pathogenesis of atherosclerosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.