ArticleInternational journal of endocrinology2011
Hypertension Secondary to PHPT: Cause or Coincidence?
Article in International journal of endocrinology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 51 citations in OpenAlex.
- Serum Parathyroid Hormone and Long-Term Mortality in Hospitalized Patients: A Real-World Cohort Study.Journal of clinical medicine · 2026Article
- Article
- Cardiovascular and metabolic status in patients with primary hyperparathyroidism: a single-center experience.Frontiers in endocrinology · 2023Article
- The preliminary study on cardiac structure and function in Chinese patients with primary hyperparathyroidism.Frontiers in endocrinology · 2023Article
- Arterial Stiffness in Thyroid and Parathyroid Disease: A Review of Clinical Studies.Journal of clinical medicine · 2022Review
- Impact of curative parathyroidectomy on left ventricular functions assessed with 2D ECHO and MUGA study.Turkish journal of surgery · 2021Article
- Serum sirtuin 1 is independently associated with intact PTH among patients with chronic kidney disease.Clinical interventions in aging · 2021Article
- Parathyroid hormone may play a role in the pathophysiology of primary hypertension.Endocrine connections · 2021Article
- The role of parathyroidectomy in treating hypertension and other cardiac manifestations of primary hyperparathyroidism.Gland surgery · 2020Review
- Endocrine Tumors Causing Arterial Hypertension: Pathophysiological Mechanisms and Clinical Implications.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2017Review
- Risk Factors for Intraoperative Hypertension during Surgery for Primary Hyperparathyroidism.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2017Article
- Association of calcium concentration with pulse pressure in older women: data from a large population-based multicentric study.The journal of nutrition, health & aging · 2014Article
- Arterial Hypertension, Metabolic Syndrome and Subclinical Cardiovascular Organ Damage in Patients with Asymptomatic Primary Hyperparathyroidism before and after Parathyroidectomy: Preliminary Results.International journal of endocrinology · 2012Article
- The Heart of the Matter: Cardiac Manifestations of Endocrine Disease.Indian journal of endocrinology and metabolismReview
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Primary hyperparathyroidism (PHPT) may be associated with arterial hypertension. The underlying mechanisms are not fully understood and reversibility by parathyroid surgery is controversial. This study aimed to characterize pressor hormones, vascular reactivity to norepinephrine, and cytosolic-free calcium in platelets in 15 hypertensive patients with hypercalcaemic PHPT before and after successful parathyroidectomy and to compare them with 5 pre-hypertensive patients with normocalcaemic PHPT, 8 normotensive patients with hypercalcaemic PHPT and 15 normal controls. Hypertensive patients with hypercalcaemic PHPT had slightly higher levels of pressor hormones (P < 0.05), enhanced cardiovascular reactivity to norepinephrine (P < 0.05) and increased cytosolic calcium in platelets (P < 0.05) than controls. Pre-hypertensive patients with normocalcaemic PHPT had intermediate values of increased cardiovascular reactivity and cytosolic calcium. Normotensive patients with hypercalcaemic PHPT and normotensive controls had comparable pressor hormone concentrations and intracellular calcium levels. Successful parathyroidectomy was associated with normal blood pressure values and normalisation of pressor hormone concentrations, cardiovascular pressor reactivity and cytosolic free calcium. Our results suggest that parathyroid hypertension is mediated/maintained, at least in part, by functional alterations of vascular smooth muscle cells and can be cured by parathyroidectomy in those patients who do not have primary hypertension.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.