ArticleFrontiers in synaptic neuroscience2010
Summing Across Different Active Zones can Explain the Quasi-Linear Ca-Dependencies of Exocytosis by Receptor Cells.
Article in Frontiers in synaptic neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- CaProceedings of the National Academy of Sciences of the United States of America · 2023Article
- Diversity matters - extending sound intensity coding by inner hair cells via heterogeneous synapses.The EMBO journal · 2023Review
- Article
- A sensory cell diversifies its output by varying CaThe EMBO journal · 2021Article
- Noise Exposure Potentiates Exocytosis From Cochlear Inner Hair Cells.Frontiers in synaptic neuroscience · 2021Article
- Phase Locking of Auditory Nerve Fibers: The Role of Lowpass Filtering by Hair Cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Phase Locking of Auditory-Nerve Fibers Reveals Stereotyped Distortions and an Exponential Transfer Function with a Level-Dependent Slope.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- High-Probability Neurotransmitter Release Sites Represent an Energy-Efficient Design.Current biology : CB · 2016Article
- New insights into cochlear sound encoding.F1000Research · 2016Review
- Elementary properties of Ca(2+) channels and their influence on multivesicular release and phase-locking at auditory hair cell ribbon synapses.Frontiers in cellular neuroscience · 2015Article
- A model of synaptic vesicle-pool depletion and replenishment can account for the interspike interval distributions and nonrenewal properties of spontaneous spike trains of auditory-nerve fibers.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Exocytotic machineries of vestibular type I and cochlear ribbon synapses display similar intrinsic otoferlin-dependent Ca2+ sensitivity but a different coupling to Ca2+ channels.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Towards a unifying basis of auditory thresholds: binaural summation.Journal of the Association for Research in Otolaryngology : JARO · 2014Article
- Developmental refinement of hair cell synapses tightens the coupling of Ca2+ influx to exocytosis.The EMBO journal · 2014Article
- Concurrent maturation of inner hair cell synaptic Ca2+ influx and auditory nerve spontaneous activity around hearing onset in mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Why longer song elements are easier to detect: threshold level-duration functions in the Great Tit and comparison with human data.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2013Article
- Exocytosis in the frog amphibian papilla.Journal of the Association for Research in Otolaryngology : JARO · 2012Article
- An improved model for the rate-level functions of auditory-nerve fibers.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Several recent studies of mature auditory and vestibular hair cells (HCs), and of visual and olfactory receptor cells, have observed nearly linear dependencies of the rate of neurotransmitter release events, or related measures, on the magnitude of Ca(2+)-entry into the cell. These relationships contrast with the highly supralinear, third to fourth power, Ca(2+)-dependencies observed in most preparations, from neuromuscular junctions to central synapses, and also in HCs from immature and various mutant animals. They also contrast with the intrinsic, biochemical, Ca(2+)-cooperativity of the ubiquitous Ca(2+)-sensors involved in fast exocytosis (synaptotagmins I and II). Here, we propose that the quasi-linear dependencies result from measuring the sum of several supralinear, but saturating, dependencies with different sensitivities at individual active zones of the same cell. We show that published experimental data can be accurately accounted for by this summation model, without the need to assume altered Ca(2+)-cooperativity or nanodomain control of release. We provide support for the proposal that the best power is 3, and we discuss the large body of evidence for our summation model. Overall, our idea provides a parsimonious and attractive reconciliation of the seemingly discrepant experimental findings in different preparations.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.