ArticleFrontiers in synaptic neuroscience2010
Questions about STDP as a General Model of Synaptic Plasticity.
Article in Frontiers in synaptic neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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50 citing papers in PubMed, 100 citations in OpenAlex.
- Irregular and bursty neuronal firing extend spike-timing dependent plasticity window to behavioral timescales.iScience · 2026Article
- The Role of Plasticity in Replay: Stability Through Anti-Hebbian Rules.Hippocampus · 2026Article
- Synaptic plasticity rules driving representational shifting in the hippocampus.Nature neuroscience · 2025Article
- Postsynaptic spiking determines anti-Hebbian LTD in visual cortex basket cells.Frontiers in synaptic neuroscience · 2025Article
- A dendritic mechanism for balancing synaptic flexibility and stability.Cell reports · 2024Article
- Dendritic excitations govern back-propagation via a spike-rate accelerometer.bioRxiv : the preprint server for biology · 2024Article
- The spike-timing-dependent plasticity of VIP interneurons in motor cortex.Frontiers in cellular neuroscience · 2024Article
- Sequence anticipation and spike-timing-dependent plasticity emerge from a predictive learning rule.Nature communications · 2023Article
- Dendritic Excitability and Synaptic Plasticity In Vitro and In Vivo.Neuroscience · 2022Review
- Local dendritic balance enables learning of efficient representations in networks of spiking neurons.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Plasticity of olfactory bulb inputs mediated by dendritic NMDA-spikes in rodent piriform cortex.eLife · 2021Article
- Distinct place cell dynamics in CA1 and CA3 encode experience in new environments.Nature communications · 2021Article
- Grand Challenge at the Frontiers of Synaptic Neuroscience.Frontiers in synaptic neuroscience · 2021Article
- Hebbian and non-Hebbian timing-dependent plasticity in the hippocampal CA3 region.Hippocampus · 2020Article
- Tonic GABAThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Synaptic Plasticity in Cortical Inhibitory Neurons: What Mechanisms May Help to Balance Synaptic Weight Changes?Frontiers in cellular neuroscience · 2020Review
- Coincidence Detection within the Excitable Rat Olfactory Bulb Granule Cell Spines.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- The Impact of Studying Brain Plasticity.Frontiers in cellular neuroscience · 2019Article
- Robustness of STDP to spike timing jitter.Scientific reports · 2018Article
- Compensatory Relearning Following Stroke: Cellular and Plasticity Mechanisms in Rodents.Frontiers in neuroscience · 2018Review
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
According to spike-timing-dependent plasticity (STDP), the timing of the Na(+) spike relative to the EPSP determines whether LTP or LTD will occur. Here, we review our reservations about STDP. Most investigations of this process have been done under conditions in which the spike is evoked by postsynaptic current injection. Under more realistic conditions, in which the spike is evoked by the EPSP, the results do not generally support STDP. For instance, low-frequency stimulation of a group of synapses can cause LTD, not the LTP predicted by the pre-before-post sequence in STDP; this is true regardless of whether or not the EPSP is large enough to produce a Na(+) spike. With stronger or more frequent stimulation, LTP can be induced by the same pre-before-post timing, but in this case block of Na(+) spikes does not necessarily prevent LTP induction. Thus, Na(+) spikes may facilitate LTP and/or LTD under some conditions, but they are not necessary, a finding consistent with their small size relative to the EPSP in many parts of pyramidal cell dendrites. The nature of the dendritic depolarizing events that control bidirectional plasticity is of central importance to understanding neural function. There are several candidates, including backpropagating action potentials, but also dendritic Ca(2+) spikes, the AMPA receptor-mediated EPSP, and NMDA receptor-mediated EPSPs or spikes. These often appear to be more important than the Na(+) spike in providing the depolarization necessary for plasticity. We thus feel that it is premature to accept STDP-like processes as the major determinant of LTP/LTD.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.