ArticleFrontiers in synaptic neuroscience2010
Spike-timing-dependent plasticity in the intact brain: counteracting spurious spike coincidences.
Article in Frontiers in synaptic neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Timing to be precise? An overview of spike timing-dependent plasticity, brain rhythmicity, and glial cells interplay within neuronal circuits.Molecular psychiatry · 2023Review
- The Degree of Nesting between Spindles and Slow Oscillations Modulates Neural Synchrony.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Tonic GABAThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Article
- Dendritic NMDA spikes are necessary for timing-dependent associative LTP in CA3 pyramidal cells.Nature communications · 2016Article
- Modulation of Synaptic Plasticity by Glutamatergic Gliotransmission: A Modeling Study.Neural plasticity · 2016Article
- Dopamine D1 and D5 receptors modulate spike timing-dependent plasticity at medial perforant path to dentate granule cell synapses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Dynamic stability of sequential stimulus representations in adapting neuronal networks.Frontiers in computational neuroscience · 2014Article
- Spike-timing-dependent plasticity: a comprehensive overview.Frontiers in synaptic neuroscience · 2012Article
- A history of spike-timing-dependent plasticity.Frontiers in synaptic neuroscience · 2011Article
- A Re-Examination of Hebbian-Covariance Rules and Spike Timing-Dependent Plasticity in Cat Visual Cortex in vivo.Frontiers in synaptic neuroscience · 2010Article
- Synaptic Plasticity in vivo: More than Just Spike-Timing?Frontiers in synaptic neuroscience · 2010Article
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Abstract
A computationally rich algorithm of synaptic plasticity has been proposed based on the experimental observation that the sign and amplitude of the change in synaptic weight is dictated by the temporal order and temporal contiguity between pre- and postsynaptic activities. For more than a decade, this spike-timing-dependent plasticity (STDP) has been studied mainly in brain slices of different brain structures and cultured neurons. Although not yet compelling, evidences for the STDP rule in the intact brain, including primary sensory cortices, have been provided lastly. From insects to mammals, the presentation of precisely timed sensory inputs drives synaptic and functional plasticity in the intact central nervous system, with similar timing requirements than the in vitro defined STDP rule. The convergent evolution of this plasticity rule in species belonging to so distant phylogenic groups points to the efficiency of STDP, as a mechanism for modifying synaptic weights, as the basis of activity-dependent development, learning and memory. In spite of the ubiquity of STDP phenomena, a number of significant variations of the rule are observed in different structures, neuronal types and even synapses on the same neuron, as well as between in vitro and in vivo conditions. In addition, the state of the neuronal network, its ongoing activity and the activation of ascending neuromodulatory systems in different behavioral conditions have dramatic consequences on the expression of spike-timing-dependent synaptic plasticity, and should be further explored.
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