ArticleFrontiers in synaptic neuroscience2010
Sharing vesicles between central presynaptic terminals: implications for synaptic function.
Article in Frontiers in synaptic neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Loss of postnatal Arx transcriptional activity in parvalbumin interneurons reveals non-cell autonomous disturbances in CA1 pyramidal cells.Neuroscience · 2024Article
- Recently recycled synaptic vesicles use multi-cytoskeletal transport and differential presynaptic capture probability to establish a retrograde net flux during ISVE in central neurons.Frontiers in cell and developmental biology · 2023Article
- Cytoskeletal regulation guides neuronal trafficking to effectively supply the synapse.Current biology : CB · 2021Review
- Deletion of β-Neurexins in Mice Alters the Distribution of Dense-Core Vesicles in Presynapses of Hippocampal and Cerebellar Neurons.Frontiers in neuroanatomy · 2021Article
- SynapseJ: An Automated, Synapse Identification Macro for ImageJ.Frontiers in neural circuits · 2021Article
- Ultrastructural and functional fate of recycled vesicles in hippocampal synapses.Nature communications · 2015Article
- Synaptic size dynamics as an effectively stochastic process.PLoS computational biology · 2014Article
- Presynaptic NCAM is required for motor neurons to functionally expand their peripheral field of innervation in partially denervated muscles.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Dynamic mechanisms of neuroligin-dependent presynaptic terminal assembly in living cortical neurons.Neural development · 2014Article
- Ultrastructural readout of functional synaptic vesicle pools in hippocampal slices based on FM dye labeling and photoconversion.Nature protocols · 2014Article
- Molecular mechanisms driving homeostatic plasticity of neurotransmitter release.Frontiers in cellular neuroscience · 2013Review
- Matching dynamics of presynaptic and postsynaptic scaffolds.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Metabolic turnover of synaptic proteins: kinetics, interdependencies and implications for synaptic maintenance.PloS one · 2013Article
- Recruitment of resting vesicles into recycling pools supports NMDA receptor-dependent synaptic potentiation in cultured hippocampal neurons.The Journal of physiology · 2012Article
- Article
- Use dependence of presynaptic tenacity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Extrasynaptic vesicle recycling in mature hippocampal neurons.Nature communications · 2011Article
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Authors and funding
2 authors.
Funding
Abstract
Presynaptic terminals in hippocampal neurons house functionally distinct vesicle pools, the size, structure and biochemical features of which are major determinants of presynaptic strength and performance. In classical models of synaptic function these vesicle pools are synapse-specific, but accumulating evidence is now demonstrating that some vesicles are laterally mobile along axons and readily shared in a functional manner across adjacent terminals. In effect then, these mobile vesicles represent a further class of synapse-spanning vesicle pool, or "superpool". Here we outline the characteristics of this additional pool type, discussing its structural organization within axons and presynaptic terminals as well as its relationship with conventional vesicle pools. We draw comparisons between extrasynaptic vesicle dynamics and the growing literature on extrasynaptic mobility of non-vesicular synaptic elements which, taken together, raise important questions about the operational independence of adjacent release sites. We also examine the functional implications of lateral vesicle sharing, from the notion that extrasynaptic vesicles can contribute to the release capabilities of individual terminals, to its potential role as a substrate for facilitating changes in synaptic weight as a basis for plasticity.
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