ArticleFrontiers in synaptic neuroscience2010
Vesicular release of glutamate utilizes the proton gradient between the vesicle and synaptic cleft.
Article in Frontiers in synaptic neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Acid-sensing ion channels emerged over 600 Mya and are conserved throughout the deuterostomes.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Proton-mediated block of Ca2+ channels during multivesicular release regulates short-term plasticity at an auditory hair cell synapse.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Kissing or fused since some time.Frontiers in synaptic neuroscience · 2010Article
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Authors and funding
6 authors.
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Abstract
Glutamate is released from synaptic vesicles following formation of a fusion pore, connecting the vesicle interior with the synaptic cleft. Release is proposed to result from either full fusion of the vesicle with the terminal membrane or by 'kiss-and-run,' where release occurs through the fusion pore. 'Kiss-and-run' seems implausible as passive diffusion of glutamate through the pore is too slow to account for the rapidity of release. Vesicular accumulation of glutamate is driven by a proton gradient, resulting in the co-release of protons during exocytosis. We tested whether the proton gradient between the vesicle and cleft contributes to glutamate exocytosis. Collapse of the gradient reduced hippocampal glutamatergic transmission, an effect that was not associated with presynaptic changes in excitability, transmitter release probability, or postsynaptic sensitivity. These data indicate that approximately half of glutamate release utilizes the proton gradient between vesicle and cleft, suggesting a significant proportion of release by 'kiss-and-run.'
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