ArticleFrontiers in synaptic neuroscience2010
Homeostatic Plasticity and STDP: Keeping a Neuron's Cool in a Fluctuating World.
Article in Frontiers in synaptic neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers.
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75 citing papers in PubMed.
- A unified model of short- and long-term plasticity: Effects on network connectivity and information capacity.PLoS computational biology · 2026Article
- Cell-Type-Specific Synaptic Scaling Mechanisms Differentially Contribute to Associative Learning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Spike-based alignment learning solves the weight transport problem.Nature communications · 2026Article
- Pridopidine, a Potent and Selective Therapeutic Sigma-1 Receptor (S1R) Agonist for Treating Neurodegenerative Diseases.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Emergence of sparse coding, balance and decorrelation from a biologically-grounded spiking neural network model of learning in the primary visual cortex.PLoS computational biology · 2025Article
- Synaptic plasticity facilitates oscillations in a V1 cortical column model with multiple interneuron types.Frontiers in computational neuroscience · 2025Article
- Co-existence of synaptic plasticity and metastable dynamics in a spiking model of cortical circuits.PLoS computational biology · 2024Article
- Co-existence of synaptic plasticity and metastable dynamics in a spiking model of cortical circuits.bioRxiv : the preprint server for biology · 2024Article
- A human in vitro neuronal model for studying homeostatic plasticity at the network level.Stem cell reports · 2023Article
- Degeneracy in epilepsy: multiple routes to hyperexcitable brain circuits and their repair.Communications biology · 2023Review
- Dendrites help mitigate the plasticity-stability dilemma.Scientific reports · 2023Article
- Creation of Neuronal Ensembles and Cell-Specific Homeostatic Plasticity through Chronic Sparse Optogenetic Stimulation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Ionic-electronic halide perovskite memdiodes enabling neuromorphic computing with a second-order complexity.Science advances · 2022Article
- A sequential two-step priming scheme reproduces diversity in synaptic strength and short-term plasticity.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Phase-change memtransistive synapses for mixed-plasticity neural computations.Nature nanotechnology · 2022Article
- ALSA: Associative Learning Based Supervised Learning Algorithm for SNN.Frontiers in neuroscience · 2022Article
- Robustness of neuronal tuning to binaural sound localization cues against age-related loss of inhibitory synaptic inputs.PLoS computational biology · 2021Article
- Altered Heterosynaptic Plasticity Impairs Visual Discrimination Learning in Adenosine A1 Receptor Knock-Out Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Homeostatic plasticity and burst activity are mediated by hyperpolarization-activated cation currents and T-type calcium channels in neuronal cultures.Scientific reports · 2021Article
- Increased Incidence of Tinnitus Following a Hyperthyroidism Diagnosis: A Population-Based Longitudinal Study.Frontiers in endocrinology · 2021Article
15 more citing papers are in PubMed but not listed here.
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2 authors.
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Abstract
Spike-timing-dependent plasticity (STDP) offers a powerful means of forming and modifying neural circuits. Experimental and theoretical studies have demonstrated its potential usefulness for functions as varied as cortical map development, sharpening of sensory receptive fields, working memory, and associative learning. Even so, it is unlikely that STDP works alone. Unless changes in synaptic strength are coordinated across multiple synapses and with other neuronal properties, it is difficult to maintain the stability and functionality of neural circuits. Moreover, there are certain features of early postnatal development (e.g., rapid changes in sensory input) that threaten neural circuit stability in ways that STDP may not be well placed to counter. These considerations have led researchers to investigate additional types of plasticity, complementary to STDP, that may serve to constrain synaptic weights and/or neuronal firing. These are collectively known as "homeostatic plasticity" and include schemes that control the total synaptic strength of a neuron, that modulate its intrinsic excitability as a function of average activity, or that make the ability of synapses to undergo Hebbian modification depend upon their history of use. In this article, we will review the experimental evidence for homeostatic forms of plasticity and consider how they might interact with STDP during development, and learning and memory.
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