ArticleFrontiers in synaptic neuroscience2009
Enhanced long-term microcircuit plasticity in the valproic Acid animal model of autism.
Article in Frontiers in synaptic neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 37 citations in OpenAlex.
- Neuroplasticity-based novel brain stimulation support intervention options for autistic population.Frontiers in human neuroscience · 2025Article
- Group I and group II metabotropic glutamate receptors are upregulated in the synapses of infant rats prenatally exposed to valproic acid.Psychopharmacology · 2023Article
- Altered Developmental Trajectory in Male and Female Rats in a Prenatal Valproic Acid Exposure Model of Autism Spectrum Disorder.Journal of autism and developmental disorders · 2023Article
- Alteration in social interaction and tactile discrimination of juvenile autistic-like rats following tactile stimulation and whisker deprivation.Brain and behavior · 2023Article
- The Role of Zinc and NMDA Receptors in Autism Spectrum Disorders.Pharmaceuticals (Basel, Switzerland) · 2022Review
- Autism Spectrum Disorder: Focus on Glutamatergic Neurotransmission.International journal of molecular sciences · 2022Review
- N-Acetylcysteine Mitigates Social Dysfunction in a Rat Model of Autism Normalizing Glutathione Imbalance and the Altered Expression of Genes Related to Synaptic Function in Specific Brain Areas.Frontiers in psychiatry · 2022Article
- Increased Expression of Kv10.2 in the Hippocampus Attenuates Valproic Acid-Induced Autism-Like Behaviors in Rats.Neurochemical research · 2019Article
- Region-Specific Reduction of BDNF Protein and Transcripts in the Hippocampus of Juvenile Rats Prenatally Treated With Sodium Valproate.Frontiers in molecular neuroscience · 2019Article
- Abnormal Development of the Earliest Cortical Circuits in a Mouse Model of Autism Spectrum Disorder.Cell reports · 2017Article
- Distinct Defects in Synaptic Differentiation of Neocortical Neurons in Response to Prenatal Valproate Exposure.Scientific reports · 2016Article
- Elevated microRNA-181c and microRNA-30d levels in the enlarged amygdala of the valproic acid rat model of autism.Neurobiology of disease · 2015Article
- Impaired Processing in the Primary Auditory Cortex of an Animal Model of Autism.Frontiers in systems neuroscience · 2015Article
- Predictable enriched environment prevents development of hyper-emotionality in the VPA rat model of autism.Frontiers in neuroscience · 2015Article
- Suppression of NMDA receptor function in mice prenatally exposed to valproic acid improves social deficits and repetitive behaviors.Frontiers in molecular neuroscience · 2015Article
- Degraded auditory processing in a rat model of autism limits the speech representation in non-primary auditory cortex.Developmental neurobiology · 2014Article
- Speech sound discrimination training improves auditory cortex responses in a rat model of autism.Frontiers in systems neuroscience · 2014Article
- Impairment of cortical GABAergic synaptic transmission in an environmental rat model of autism.The international journal of neuropsychopharmacology · 2013Article
- General developmental health in the VPA-rat model of autism.Frontiers in behavioral neuroscience · 2013Article
- A synaptic organizing principle for cortical neuronal groups.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A single intra-peritoneal injection of valproic acid (VPA) on embryonic day (ED) 11.5 to pregnant rats has been shown to produce severe autistic-like symptoms in the offspring. Previous studies showed that the microcircuitry is hyperreactive due to hyperconnectivity of glutamatergic synapses and hyperplastic due to over-expression of NMDA receptors. These changes were restricted to the dimensions of a minicolumn (<50 μm). In the present study, we explored whether Long Term Microcircuit Plasticity (LTMP) was altered in this animal model. We performed multi-neuron patch-clamp recordings on clusters of layer 5 pyramidal cells in somatosensory cortex brain slices (PN 12-15), mapped the connectivity and characterized the synaptic properties for connected neurons. Pipettes were then withdrawn and the slice was perfused with 100 μM sodium glutamate in artificial cerebrospinal fluid in the recording chamber for 12 h. When we re-patched the same cluster of neurons, we found enhanced LTMP only at inter-somatic distances beyond minicolumnar dimensions. These data suggest that hyperconnectivity is already near its peak within the dimensions of the minicolumn in the treated animals and that LTMP, which is normally restricted to within a minicolumn, spills over to drive hyperconnectivity across the dimensions of a minicolumn. This study provides further evidence to support the notion that the neocortex is highly plastic in response to new experiences in this animal model of autism.
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