ArticleFrontiers in physiology2010
Ammonia production, excretion, toxicity, and defense in fish: a review.
Article in Frontiers in physiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 131 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
131 citing papers in PubMed, 468 citations in OpenAlex.
- Multi-Omics Analysis of Hepatopancreatic Responses to Ammonia Nitrogen Stress in Diploid Pacific Oysters (Animals : an open access journal from MDPI · 2026Article
- L-Glutamine Plus L-Glutamic Acid Enhances Antioxidant Status and Ammonia Toxicity Resilience, Upregulates Interleukin IL-10 Gene, and Improves Gut Microbiota and Survival in Juvenile Nile Tilapia.Journal of animal physiology and animal nutrition · 2026Article
- Single-Cell Transcriptomics and Metabolomics Reveal Glutamate Dehydrogenase as a Central Regulator of Nitrogen Metabolic Remodeling During Alkalinity Adaptation in Crustaceans.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Chronic ammonia nitrogen induces integrated metabolic and immune reprogramming in the hepatopancreas of Macrobrachium rosenbergii.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2026Article
- High-throughput multispecies quantitative polymerase chain reaction assays to study the effects of acute thermal stress in three species of Acipenser sturgeon.Journal of fish biology · 2026Article
- Regulatory mechanisms of nitrogen homeostasis in insect growth and development.Insect science · 2026Review
- Dietary L-Ornithine L-Aspartate Alleviates Ammonia Load and Improves Hepatic Health in Largemouth Bass (Animals : an open access journal from MDPI · 2026Article
- Multi-Tissue Transcriptomics Analysis of the Effects of Ammonia Nitrogen Stress on Metabolism, Immunity, and Comprehensive Stress Responses inAnimals : an open access journal from MDPI · 2026Article
- Effects of Stocking Density and Body Size on Oxygen Consumption and Ammonia Excretion in Silverside (Animals : an open access journal from MDPI · 2026Article
- Article
- Tissue-Specific Redistribution of Free Amino Acids in Mandarin Fish (Life (Basel, Switzerland) · 2026Article
- Physiological Effects of Dietary Protein and Its Optimal Requirement for Early Juvenile Chinese Tapertail Anchovy (Animals : an open access journal from MDPI · 2026Article
- Lack of gastric acidification reduces postprandial energy expenditure and protein digestion but not growth in Astyanax mexicanus.The Journal of experimental biology · 2026Article
- Natural liquid betaine dietary supplementation improves growth performance, immuno-antioxidant responses, and stress resistance in Nile tilapia subjected to acute ammonia challenge.Scientific reports · 2026Article
- Ammonia Exposure Elevated 5-HT Expression, Reprogrammed Transcriptome and Microbiota Community in Yellow Catfish (Microorganisms · 2026Article
- Acute Total Ammonia Nitrogen (TAN) stress affects the skin metabolism, antioxidant capacity, immune function, and tissue structure of juvenile yellowfin tuna (Thunnus albacares).Fish physiology and biochemistry · 2026Article
- Response of epithelial cell lines from the rainbow trout gut and gill to ammonia.In vitro cellular & developmental biology. Animal · 2026Article
- Oxygen consumption from air and water, ammonia and urea-N excretion, and NaJournal of fish biology · 2026Article
- Aquatic Moss Mats Are Alternative Biofilter Media for Aquaculture and Aquaponic Effluents Treating.Plants (Basel, Switzerland) · 2026Article
- Effects of elevated carbon dioxide on growth, feed efficiency and physiological responses in RAS-based juvenile pikeperch (Frontiers in veterinary science · 2026Article
71 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many fishes are ammonotelic but some species can detoxify ammonia to glutamine or urea. Certain fish species can accumulate high levels of ammonia in the brain or defense against ammonia toxicity by enhancing the effectiveness of ammonia excretion through active NH4+transport, manipulation of ambient pH, or reduction in ammonia permeability through the branchial and cutaneous epithelia. Recent reports on ammonia toxicity in mammalian brain reveal the importance of permeation of ammonia through the blood-brain barrier and passages of ammonia and water through transporters in the plasmalemma of brain cells. Additionally, brain ammonia toxicity could be related to the passage of glutamine through the mitochondrial membranes into the mitochondrial matrix. On the other hand, recent reports on ammonia excretion in fish confirm the involvement of Rhesus glycoproteins in the branchial and cutaneous epithelia. Therefore, this review focuses on both the earlier literature and the up-to-date information on the problems and mechanisms concerning the permeation of ammonia, as NH(3), NH4+ or proton-neutral nitrogenous compounds, across mitochondrial membranes, the blood-brain barrier, the plasmalemma of neurons, and the branchial and cutaneous epithelia of fish. It also addresses how certain fishes with high ammonia tolerance defend against ammonia toxicity through the regulation of the permeation of ammonia and related nitrogenous compounds through various types of membranes. It is hoped that this review would revive the interests in investigations on the passage of ammonia through the mitochondrial membranes and the blood-brain barrier of ammonotelic fishes and fishes with high brain ammonia tolerance, respectively.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.