ArticlePLoS medicine2011
Predicting harms and benefits in translational trials: ethics, evidence, and uncertainty.
Article in PLoS medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Who should be included in first-in-human trials? A systematic review of reasons.Journal of translational medicine · 2025Pooled it
- Risk of surgical delivery to deep nuclei: a meta-analysis.Movement disorders : official journal of the Movement Disorder Society · 2011Pooled it
- Designer Organs: Ethical Genetic Modifications in the Era of Machine Perfusion.Annual review of biomedical engineering · 2025Review
- Supporting evidence in phase 2 cancer trial protocols: a content analysis.Journal of the National Cancer Institute · 2025Article
- States of Uncertainty, Risk-Benefit Assessment and Early Clinical Research: A Conceptual Investigation.Science and engineering ethics · 2022Article
- Ethical challenges for a new generation of early-phase pediatric gene therapy trials.Genetics in medicine : official journal of the American College of Medical Genetics · 2021Review
- Ethics of HIV cure research: an unfinished agenda.BMC medical ethics · 2021Review
- Article
- Acute respiratory distress syndrome subphenotypes and therapy responsive traits among preclinical models: protocol for a systematic review and meta-analysis.Respiratory research · 2020Article
- Joining forces: the need to combine science and ethics to address problems of validity and translation in neuropsychiatry research using animal models.Philosophy, ethics, and humanities in medicine : PEHM · 2020Article
- A few ethical issues in translational research for gene and cell therapy.Journal of translational medicine · 2019Article
- Marketing the Research Missions of Academic Medical Centers: Why Messages Blurring Lines Between Clinical Care and Research Are Bad for both Business and Ethics.Cambridge quarterly of healthcare ethics : CQ : the international journal of healthcare ethics committees · 2019Article
- Ethical considerations for HIV cure-related research at the end of life.BMC medical ethics · 2018Article
- The Shared Ethical Responsibility of Medically and Non-medically Qualified Experts in Human Drug Development Teams.Frontiers in pharmacology · 2018Article
- Risk Assessment and Risk Minimization in Nanomedicine: A Need for Predictive, Alternative, and 3Rs Strategies.Frontiers in pharmacology · 2018Review
- Research on HIV cure: Mapping the ethics landscape.PLoS medicine · 2017Article
- How to keep high-risk studies ethical: classifying candidate solutions.Journal of medical ethics · 2017Article
- First-in-human Phase 1 CRISPR Gene Editing Cancer Trials: Are We Ready?Current gene therapy · 2017Article
- Stakeholder views on participant selection for first-in-human trials in cancer nanomedicine.Current oncology (Toronto, Ont.) · 2016Article
- Defining Nano, Nanotechnology and Nanomedicine: Why Should It Matter?Science and engineering ethics · 2016Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
PubMed holds no abstract for this paper.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.