ArticleObstetrics and gynecology2011
Body mass index in early adulthood and endometrial cancer risk for mismatch repair gene mutation carriers.
Article in Obstetrics and gynecology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Energy balance related lifestyle factors and risk of endometrial and colorectal cancer among individuals with lynch syndrome: a systematic review.Familial cancer · 2019Pooled it
- Selective Inhibition of Proofreading Exonucleases: The Central Role in Obesity-Associated Carcinogenesis.Current issues in molecular biology · 2026Review
- A New Inverse Probability of Selection Weighted Cox Model to Deal With Outcome-Dependent Sampling in Survival Analysis.Biometrical journal. Biometrische Zeitschrift · 2025Article
- An effective algorithm to detect the possibility of being MSI phenotype in endometrial cancer given the BMI status and histological subtype: a statistical study.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2022Article
- Cohort Profile: The Colon Cancer Family Registry Cohort (CCFRC).International journal of epidemiology · 2018Article
- Comparison of lifestyle, hormonal and medical factors in women with sporadic and Lynch syndrome-associated endometrial cancer: A retrospective case-case study.Molecular and clinical oncology · 2017Article
- Endometrial cancer risk factors among Lynch syndrome women: a retrospective cohort study.British journal of cancer · 2016Article
- Impact of DNA mismatch repair system alterations on human fertility and related treatments.Journal of Zhejiang University. Science. B · 2016Review
- Aspirin, Ibuprofen, and the Risk of Colorectal Cancer in Lynch Syndrome.Journal of the National Cancer Institute · 2015Article
- Article
- Body mass index at early adulthood, subsequent weight change and cancer incidence and mortality.International journal of cancer · 2014Article
- The genetic basis of Lynch syndrome and its implications for clinical practice and risk management.The application of clinical genetics · 2014Review
- Anthropometric measures and the risk of endometrial cancer, overall and by tumor microsatellite status and histological subtype.American journal of epidemiology · 2013Article
- Do lifestyle factors influence colorectal cancer risk in Lynch syndrome?Familial cancer · 2013Review
- Cancer risks for MLH1 and MSH2 mutation carriers.Human mutation · 2013Article
- Body mass index in early adulthood and colorectal cancer risk for carriers and non-carriers of germline mutations in DNA mismatch repair genes.British journal of cancer · 2011Article
Corrections and comments
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Authors and funding
19 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo investigate the association of body mass index (BMI) in early adulthood and endometrial cancer risk for carriers of a germline mutation in a DNA mismatch repair gene.
methodsWe estimated the association between BMI at age 18-20 years and endometrial cancer risk for mismatch repair gene mutation carriers and, as a comparison group, noncarriers using 601 female carriers of a germline mutation in a mismatch repair gene (245 MLH1, 299 MSH2, 38 MSH6, and 19 PMS2) and 533 female noncarriers from the Colon Cancer Family Registry using a weighted Cox proportional hazards regression.
resultsDuring 51,693 person-years of observation, we observed diagnoses of endometrial cancer for 126 carriers and eight noncarriers. For carriers, there was no evidence of an association between BMI at age 20 years and endometrial cancer (adjusted hazard ratio 0.73 per 5 kg/m²; 95% confidence interval [CI], 0.40-1.34; P=.31). For noncarriers, endometrial cancer risk increased by 74% for each 5-kg/m² increment in BMI (adjusted hazard ratio 1.74; 95% CI 1.27-2.37; P<.001). The hazard ratio for BMI and endometrial cancer for noncarriers was greater than for carriers (P=.04).
conclusionThe effect of body mass on endometrial cancer risk depends on the woman's mismatch repair gene mutation carrier status, suggesting obesity-independent endometrial carcinogenesis for carriers. LEVEL OF EVIDENCE: II.
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