Evidence map›Paper›PMID 21422850›Full record

ArticleObstetrics and gynecology2011

Antimüllerian hormone as a predictor of natural fecundability in women aged 30-42 years.

Anne Z Steiner, Amy H Herring, James S Kesner, Juliana W Meadows, Frank Z Stanczyk, Steven Hoberman, Donna D Baird

Registry-linked trialAbstract read
In one paragraph

Article in Obstetrics and gynecology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01028365 (Time to Conceive), which is not on this map. Cited by 72 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
72citing papers in PubMed, 3 pooled it
16.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01028365 completednot on this map

Time to Conceive: A Study of Fertility: Biomarkers of Fertility

TypeobservationalSponsorUniversity of North Carolina, Chapel HillRan2008 to 2016Enrolled843ConditionsHealthyArmsNo intervention
3 · Its place in the literature

Who cites it

72 citing papers in PubMed, 3 syntheses or guidelines pooled it, 169 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Is Anti-Müllerian Hormone Associated With Fecundability? Findings From the EAGeR Trial.The Journal of clinical endocrinology and metabolism · 2015
    Trial
  5. Trial
  6. Impact of cancer therapies on ovarian reserve.Fertility and sterility · 2012
    Trial
  7. Article
  8. Article
  9. Article
  10. Inflammation and Ovarian Function in Reproductive-Aged Women.American journal of human biology : the official journal of the Human Biology Council · 2025
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article

12 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Anne Z SteinerFrom the Departments of Obstetrics and Gynecology and Biostatistics, University of North Carolina, Chapel Hill, North Carolina; the National Institute for Occupational Safety and Health, Cincinnati, Ohio; the Department of Obstetrics and Gynecology and Preventive Medicine, University of Southern California, Los Angeles, California; and the Epidemiology Branch, National Institute of Environmental Health Science/National Institutes of Health, Research Triangle Park, North Carolina.
Amy H Herring
James S Kesner
Juliana W Meadows
Frank Z Stanczyk
Steven Hoberman
Donna D Baird
National Institute of Environmental Health Sciences · US

Funding

UNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Stephanie Engel · 2001 to 2026
$36.3M
Carolina Population CenterR24HD050924 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MORGAN, SAMUEL PHILIP · 2005 to 2014
$10.0M
WRHR Career Development Center at UNCK12HD050113 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI CLARKE-PEARSON, DANIEL LYLE · 2005 to 2009
$1.7M
Time to ConceiveR21HD060229 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI STEINER, ANNE ZWEIFEL · 2009 to 2010
$407k
Intramural NIH HHSNICHD NIH HHS 5 K12 HD050113NICHD NIH HHS K12 HD050113NICHD NIH HHS R21 HD060229NICHD NIH HHS R24 HD050924NIEHS NIH HHS P30 ES010126
6 · The paper itself

Abstract

objectiveTo generate estimates of the association between markers of ovarian aging and natural fertility in a community sample at risk for ovarian aging.

methodsWomen aged 30-44 years with no history of infertility who had been trying to conceive for less than 3 months provided early-follicular phase serum and urine (N=100). Subsequently, these women kept a diary to record menstrual bleeding and intercourse and conducted standardized pregnancy testing for up to 6 months. Serum was analyzed for estradiol, follicle-stimulating hormone (FSH), antimüllerian hormone, and inhibin B. Urine was analyzed for FSH and estrone 3-glucuronide. Diary data on menstrual cycle day and patterns of intercourse were used to calculate day-specific fecundability ratios.

resultsSixty-three percent of participants conceived within 6 months. After adjusting for age, 18 women (18%) with serum antimüllerian hormone levels of 0.7 ng/mL or less had significantly reduced fecundability given intercourse on a fertile day compared with women with higher antimüllerian hormone levels (fecundability ratio 0.38; 95% confidence interval [CI] 0.08-0.91). The day-specific fecundability for women with early-follicular phase serum FSH values greater than 10 milli-international units/mL compared with women with lower FSH levels was also reduced, although nonsignificantly (11% of women affected; fecundability ratio 0.44; 95% CI 0.08-1.10). The association with urinary FSH was weaker (27% women affected; fecundability ratio 0.61; 95% CI 0.26-1.26), and the associations for the other markers were weaker still.

conclusionEarly-follicular phase antimüllerian hormone appears to be associated with natural fertility in the general population. LEVEL OF EVIDENCE: II.

Indexed as

Maternal AgeAdultAnti-Mullerian HormoneBiomarkersCohort StudiesConfidence IntervalsEstradiolFemaleFertilityFollicle Stimulating HormoneHumansInhibinsPredictive Value of TestsPregnancyPregnancy RateRisk FactorsAnti-Mullerian HormoneBiomarkersEstradiolFollicle Stimulating Hormoneinhibin BInhibins

Identifiers

PMID21422850
PMCPMC3825553
OpenAlexW2073306807

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.