ArticleJournal of vestibular research : equilibrium & orientation2011
Intrinsic physiology of identified neurons in the prepositus hypoglossi and medial vestibular nuclei.
Article in Journal of vestibular research : equilibrium & orientation, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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Who cites it
12 citing papers in PubMed, 28 citations in OpenAlex.
- Article
- A novelFrontiers in cellular neuroscience · 2024Article
- The role of GABAB receptors in the vestibular oculomotor system in mice.Behavioural brain research · 2016Article
- Muscarinic receptor subtypes differentially control synaptic input and excitability of cerebellum-projecting medial vestibular nucleus neurons.Journal of neurochemistry · 2016Article
- A structural and genotypic scaffold underlying temporal integration.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Purkinje cell responses during visually and vestibularly driven smooth eye movements in mice.Brain and behavior · 2015Article
- Neuronal classification and marker gene identification via single-cell expression profiling of brainstem vestibular neurons subserving cerebellar learning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Lobule-specific membrane excitability of cerebellar Purkinje cells.The Journal of physiology · 2012Article
- Plasticity of spontaneous excitatory and inhibitory synaptic activity in morphologically defined vestibular nuclei neurons during early vestibular compensation.Journal of neurophysiology · 2012Article
- Basic Concepts in Understanding Recovery of Function in Vestibular Reflex Networks during Vestibular Compensation.Frontiers in neurology · 2012Article
- Diverse precerebellar neurons share similar intrinsic excitability.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Signal processing in the vestibular system is influenced by the intrinsic physiological properties of neurons that differ in neurotransmitters and circuit connections. Do membrane and firing properties differ across functionally distinct cell types? This study examines the intrinsic physiology of neurons in the medial vestibular nucleus (MVN) and nucleus prepositus hypoglossi (NPH) which express different neurotransmitters and have distinct axonal projections. NPH neurons expressing fluorescent proteins in glutamatergic, glycinergic, or GABAergic neurons were targeted for whole-cell patch recordings in brainstem slices obtained from transgenic mouse lines (YFP-16, GlyT2, and GIN). Recordings from MVN neurons projecting to the spinal cord, reticular formation, or oculomotor nucleus were obtained by targeting fluorescent neurons retrogradely labeled from tracer injections. Intrinsic physiological properties of identified neurons exhibited continuous variations but tended to differ between functionally defined cell types. Within the NPH, YFP-16 neurons had the narrowest action potentials and highest evoked firing rates and expressed high levels of Kv3.3 proteins, which speed repolarization. MVN neurons projecting to the spinal cord and oculomotor nucleus had similar action potential waveforms, but oculomotor-projecting neurons had higher intrinsic gains than those projecting to the spinal cord. These results indicate that intrinsic membrane properties are differentially tuned in MVN and NPH neurons subserving different functions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.