ArticleIEEE/ACM transactions on computational biology and bioinformatics
Transactional database transformation and its application in prioritizing human disease genes.
Article in IEEE/ACM transactions on computational biology and bioinformatics. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- BLAT2DOLite: An Online System for Identifying Significant Relationships between Genetic Sequences and Diseases.PloS one · 2016Article
- Enabling online studies of conceptual relationships between medical terms: developing an efficient web platform.JMIR medical informatics · 2014Article
- k-Neighborhood decentralization: a comprehensive solution to index the UMLS for large scale knowledge discovery.Journal of biomedical informatics · 2012Article
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3 authors.
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Abstract
Binary (0,1) matrices, commonly known as transactional databases, can represent many application data, including genephenotype data where “1” represents a confirmed gene-phenotype relation and “0” represents an unknown relation. It is natural to ask what information is hidden behind these “0”s and “1”s. Unfortunately, recent matrix completion methods, though very effective in many cases, are less likely to infer something interesting from these (0,1)-matrices. To answer this challenge, we propose INDEVI, a very succinct and effective algorithm to perform independent-evidence-based transactional database transformation. Each entry of a (0,1)-matrix is evaluated by “independent evidence” (maximal supporting patterns) extracted from the whole matrix for this entry. The value of an entry, regardless of its value as 0 or 1, has completely no effect for its independent evidence. The experiment on a genephenotype database shows that our method is highly promising in ranking candidate genes and predicting unknown disease genes.
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