Trial reportArchives of otolaryngology--head & neck surgery2011
Low-frequency repetitive transcranial magnetic stimulation to the temporoparietal junction for tinnitus.
Trial report in Archives of otolaryngology--head & neck surgery, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 22 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Collaborative Tinnitus Research at Washington University
rTMS Bimodal Treatment For Patients With Subjective Idiopathic Tinnitus: A Pilot Study
Who cites it
22 citing papers in PubMed, 4 syntheses or guidelines pooled it, 64 citations in OpenAlex.
- Efficacy of repetitive transcranial magnetic stimulation for subjective chronic tinnitus: a randomized controlled trial meta-analysis.Frontiers in neuroscience · 2025Pooled it
- RTMS parameters in tinnitus trials: a systematic review.Scientific reports · 2019Pooled it
- A multidisciplinary systematic review of the treatment for chronic idiopathic tinnitus.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2017Pooled it
- Safety and tolerability of repetitive transcranial magnetic stimulation in patients with pathologic positive sensory phenomena: a review of literature.Brain stimulation · 2012Pooled it
- The effect of noninvasive brain stimulation on neural connectivity in Tinnitus: A randomized trial.The Laryngoscope · 2016Trial
- Combined rTMS treatment targeting the Anterior Cingulate and the Temporal Cortex for the Treatment of Chronic Tinnitus.Scientific reports · 2015Trial
- Low-frequency repetitive transcranial magnetic stimulation to the temporoparietal junction for tinnitus: four-week stimulation trial.JAMA otolaryngology-- head & neck surgery · 2013Trial
- Altered networks in bothersome tinnitus: a functional connectivity study.BMC neuroscience · 2012Trial
- Transdermal lidocaine as treatment for chronic subjective tinnitus: A pilot study.American journal of otolaryngologyTrial
- Neuronavigated Versus Non-navigated Repetitive Transcranial Magnetic Stimulation for Chronic Tinnitus: A Randomized Study.Trends in hearingTrial
- Trial
- Effect of Ipsilateral, Contralateral or Bilateral Repetitive Transcranial Magnetic Stimulation in Patients with Lateralized Tinnitus: A Placebo-Controlled Randomized Study.Brain sciences · 2022Article
- Sequential Prefrontal and Temporoparietal Repetitive Transcranial Magnetic Stimulation (rTMS) for Treatment of Tinnitus With and Without Comorbid Depression: A Case Series and Systematic Review.Frontiers in neurology · 2022Article
- Tinnitus Update.Journal of clinical neurology (Seoul, Korea) · 2021Review
- Association of Central Noninvasive Brain Stimulation Interventions With Efficacy and Safety in Tinnitus Management: A Meta-analysis.JAMA otolaryngology-- head & neck surgery · 2020Article
- Transcranial Magnetic Stimulation as a Therapeutic Option for Neurologic and Psychiatric Illnesses.Cureus · 2018Review
- A Series of Case Studies of Tinnitus Suppression With Mixed Background Stimuli in a Cochlear Implant.American journal of audiology · 2015Article
- Low-frequency transcranial magnetic stimulation is beneficial for enhancing synaptic plasticity in the aging brain.Neural regeneration research · 2015Article
- Short term effects of repetitive transcranial magnetic stimulation in patients with catastrophic intractable tinnitus: preliminary report.Clinical and experimental otorhinolaryngology · 2013Article
- Laterality, frequency and replication of rTMS treatment for chronic tinnitus: pilot studies and a review of maintenance treatment.Hearing research · 2013Review
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo examine the effectiveness and safety of low-frequency repetitive transcranial magnetic stimulation (rTMS) to the temporoparietal junction in a cohort of patients with bothersome tinnitus.
designCrossover, double-blind, randomized clinical trial.
settingOutpatient academic medical center.
participantsFourteen adults aged 42 to 59 years with subjective, unilateral or bilateral, nonpulsatile tinnitus of 6 months' duration or longer and a score of 38 or greater on the Tinnitus Handicap Inventory (THI).
interventionsLow-frequency (1-Hz) 110% motor threshold rTMS or sham treatment to the left temporoparietal junction for 2 weeks.
main outcome measureThe difference in the change of the THI score between active and sham rTMS.
resultsActive treatment was associated with a median (95% confidence interval) reduction in THI score of 5 (0-14) points, and sham treatment was associated with a median reduction in THI score of 6 (-2 to 12) points. The difference in THI scores between the change associated with active and sham rTMS ranged from a 34-point reduction in THI score after active treatment to a 22-point increase after sham treatment, with a median difference change of only 1 point (-6 to 4 points).
conclusionsDaily low-frequency rTMS to the left temporoparietal junction area for 2 weeks is no more effective than placebo for patients with chronic bothersome tinnitus. Possible explanations for the negative findings are short duration of treatment, failure of rTMS stimulation over the temporoparietal area to affect the auditory cortex buried within the Sylvian fissure, or more widespread cortical network changes associated with severe bothersome tinnitus not amenable to localized rTMS effects. Trial Registration clinicaltrials.gov Identifier: NCT00567892.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.