ArticleProceedings of the National Academy of Sciences of the United States of America2011
Electrostatic influences of charged inner pore residues on the conductance and gating of small conductance Ca2+ activated K+ channels.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Restoration of mitochondrial CaJournal of molecular and cellular cardiology · 2026Article
- Cryo-EM structures of the small-conductance CaNature communications · 2025Article
- The Inhibition of the Small-Conductance CaPharmaceuticals (Basel, Switzerland) · 2022Article
- Impact of IBiophysical journal · 2020Article
- PKA phosphorylation underlies functional recruitment of sarcolemmal SK2 channels in ventricular myocytes from hypertrophic hearts.The Journal of physiology · 2020Article
- A biophysically detailed computational model of urinary bladder small DRG neuron soma.PLoS computational biology · 2018Article
- Activation mechanism of a human SK-calmodulin channel complex elucidated by cryo-EM structures.Science (New York, N.Y.) · 2018Article
- Apamin-sensitive calcium-activated potassium currents in rabbit ventricles with chronic myocardial infarction.Journal of cardiovascular electrophysiology · 2013Article
- Ca(V)1.3-driven SK channel activation regulates pacemaking and spike frequency adaptation in mouse chromaffin cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Trafficking of intermediate (KCa3.1) and small (KCa2.x) conductance, Ca(2+)-activated K(+) channels: a novel target for medicinal chemistry efforts?ChemMedChem · 2012Review
- Protective Roles for Potassium SK/K(Ca)2 Channels in Microglia and Neurons.Frontiers in pharmacology · 2012Article
- Crucial role of a shared extracellular loop in apamin sensitivity and maintenance of pore shape of small-conductance calcium-activated potassium (SK) channels.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
Corrections and comments
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Authors and funding
2 authors.
Funding
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Abstract
SK channels underlie important physiological functions by linking calcium signaling with neuronal excitability. Potassium currents through SK channels demonstrate inward rectification, which further reduces their small outward conductance. Although it has been generally attributed to block of outward current by intracellular divalent ions, we find that inward rectification is in fact an intrinsic property of SK channels independent of intracellular blockers. We identified three charged residues in the S6 transmembrane domain of SK channels near the inner mouth of the pore that collectively control the conductance and rectification through an electrostatic mechanism. Additionally, electrostatic contributions from these residues also play an important role in determining the intrinsic open probability of SK channels in the absence of Ca(2+), affecting the apparent Ca(2+) affinity for activation.
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