ArticleInternational immunology2011
CCR6hiCD11c(int) B cells promote M-cell differentiation in Peyer's patch.
Article in International immunology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.
- Identification of novel genes selectively expressed in the follicle-associated epithelium from the meta-analysis of transcriptomics data from multiple mouse cell and tissue populations.DNA research : an international journal for rapid publication of reports on genes and genomes · 2012Pooled it
- Comprehensive characterisation of age-related changes in cell subpopulations and tissue structural properties in secondary lymphoid organs.Cell death & disease · 2025Article
- Biomarker expression level changes within rectal gut-associated lymphoid tissues in spinal cord-injured rats.ImmunoHorizons · 2025Article
- Deciphering the M-cell niche: insights from mouse models on how microfold cells "know" where they are needed.Frontiers in immunology · 2024Review
- Differential role of M cells in enteroid infection byFrontiers in cellular and infection microbiology · 2024Article
- The impact of aging on intestinal mucosal immune function and clinical applications.Frontiers in immunology · 2022Review
- Gut microbiota alterations and health status in aging adults: From correlation to causation.Aging medicine (Milton (N.S.W)) · 2021Review
- B and T Cell Immunity in Tissues and Across the Ages.Vaccines · 2021Review
- Aging-Related Impairments to M Cells in Peyer's Patches Coincide With Disturbances to Paneth Cells.Frontiers in immunology · 2021Article
- Article
- Activated Peyer's patch B cells sample antigen directly from M cells in the subepithelial dome.Nature communications · 2019Article
- The Roles of Peyer's Patches and Microfold Cells in the Gut Immune System: Relevance to Autoimmune Diseases.Frontiers in immunology · 2019Review
- Characterization of Vibrio cholerae neuraminidase as an immunomodulator for novel formulation of oral allergy immunotherapy.Clinical immunology (Orlando, Fla.) · 2018Article
- The role of CSF1R-dependent macrophages in control of the intestinal stem-cell niche.Nature communications · 2018Article
- CD11c+ T-bet+ memory B cells: Immune maintenance during chronic infection and inflammation?Cellular immunology · 2017Review
- Identification of subepithelial mesenchymal cells that induce IgA and diversify gut microbiota.Nature immunology · 2017Article
- Tissue adaptation: Implications for gut immunity and tolerance.The Journal of experimental medicine · 2017Review
- c-Rel is dispensable for the differentiation and functional maturation of M cells in the follicle-associated epithelium.Immunobiology · 2017Article
- The Peyer's Patch Mononuclear Phagocyte System at Steady State and during Infection.Frontiers in immunology · 2017Review
- IgA production requires B cell interaction with subepithelial dendritic cells in Peyer's patches.Science (New York, N.Y.) · 2016Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
M cells are responsible for uptake of mucosal antigens in Peyer's patches (PPs). Differentiation of M cells is thought to be induced by interactions between follicle-associated epithelium and PP cells; however, it remains elusive what types of immune cells function as M-cell inducers. Here, we attempted to identify the cells that serve as an M-cell inducer in PP. We found that a unique B-cell subset characterized by CCR6(hi)CD11c(int) resided in the subepithelial dome (SED) in mouse PP. CCR6(hi)CD11c(int) B cells showed chemotactic migration in response to CCL20. Furthermore, this unique B-cell subset substantially decreased in PP of CCR6-deficient mice, indicating that the SED localization of CCR6(hi)CD11c(int) B cells is most likely regulated by the CCL20-CCR6 system. Concomitantly, CCR6 deficiency caused remarkable decrement of M cells. Moreover, adoptive transfer of CCR6(hi)CD11c(int) B cells from wild-type mice restored the M-cell decrement in CCR6-deficient mice. Collectively, the spatial regulation of CCR6(hi)CD11c(int) B cells via the CCL20-CCR6 system may play a vital role in M-cell differentiation in mice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.