ArticleInvestigative ophthalmology & visual science2011
A class I (Senofilcon A) soft contact lens prevents UVB-induced ocular effects, including cataract, in the rabbit in vivo.
Article in Investigative ophthalmology & visual science, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The trial behind it
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Who cites it
12 citing papers in PubMed.
- Action Spectrum of Visible Light for Human Lens Epithelial Cell Migration In Vitro.Translational vision science & technology · 2025Article
- Poly(Sulfobetaine Methacrylate-co-Vinyl Pyrrolidone) Hydrogels as Potential Contact Lenses Delivery Systems for Timolol Maleate.Gels (Basel, Switzerland) · 2023Article
- UV light-blocking contact lenses protect against short-term UVB-induced limbal stem cell niche damage and inflammation.Scientific reports · 2018Article
- UVB promotes the initiation of uveitic inflammatory injury in vivo and is attenuated by UV-blocking protection.Molecular vision · 2017Article
- Integrin αVβ5-mediated Removal of Apoptotic Cell Debris by the Eye Lens and Its Inhibition by UV Light Exposure.The Journal of biological chemistry · 2015Article
- The mechanism of UVB irradiation induced-apoptosis in cataract.Molecular and cellular biochemistry · 2015Article
- UV-blocking spectacle lens protects against UV-induced decline of visual performance.Molecular vision · 2015Article
- Tyrosine/cysteine cluster sensitizing human γD-crystallin to ultraviolet radiation-induced photoaggregation in vitro.Biochemistry · 2014Article
- Assessment of ultraviolet B-blocking effects of weekly disposable contact lenses on corneal surface in a mouse model.Molecular vision · 2013Article
- A Class I UV-blocking (senofilcon A) soft contact lens prevents UVA-induced yellow fluorescence and NADH loss in the rabbit lens nucleus in vivo.Experimental eye research · 2012Article
- Inhibition of lens photodamage by UV-absorbing contact lenses.Investigative ophthalmology & visual science · 2011Article
- Tryptophan cluster protects human γD-crystallin from ultraviolet radiation-induced photoaggregation in vitro.Photochemistry and photobiologyArticle
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
purposeUVB radiation from sunlight is known to be a risk factor for human cataract. The purpose in this study was to investigate the ability of a class I UV-blocking soft contact lens to protect against UVB-induced effects on the ocular tissues of the rabbit in vivo.
methodsEyes of rabbits were exposed to UVB light for 30 minutes (270-360 nm, peak at 310 nm, 1.7 mW/cm(2) on the cornea). Eyes were irradiated in the presence of either a UV-blocking senofilcon A contact lens, a minimally UV-blocking lotrafilcon A contact lens, or no contact lens at all. Effects on the cornea and lens were evaluated at various times after exposure.
resultsEyes irradiated with no contact lens protection showed corneal epithelial cell loss plus lens epithelial cell swelling, vacuole formation, and DNA single-strand breaks, as well as lens anterior subcapsular opacification. The senofilcon A lens protected nearly completely against the UVB-induced effects, whereas the lotrafilcon A lens showed no protection.
conclusionsThe results indicate that use of a senofilcon A contact lens is beneficial in protecting ocular tissues of the rabbit against the harmful effects of UVB light, including photokeratitis and cataract.
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