ArticleAmerican journal of physiology. Heart and circulatory physiology2011
Hyperbaric hyperoxia reduces exercising forearm blood flow in humans.
Article in American journal of physiology. Heart and circulatory physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 32 citations in OpenAlex.
- Effects of Oxygen on Perioperative Vascular Function: A Randomized Clinical Trial.Journal of the American Heart Association · 2025Trial
- Effect of vitamin C on hyperoxia-induced vasoconstriction in exercising skeletal muscle.Journal of applied physiology (Bethesda, Md. : 1985) · 2014Trial
- Vasoconstrictor responsiveness during hyperbaric hyperoxia in contracting human muscle.Journal of applied physiology (Bethesda, Md. : 1985) · 2013Trial
- Carotid chemoreceptor modulation of blood flow during exercise in healthy humans.The Journal of physiology · 2011Trial
- Effects of mild hyperbaric oxygen therapy on timing sequence recovery of muscle fatigue in cJournal of exercise science and fitness · 2024Article
- The Acute Effect of Hyperoxia on Onset of Blood Lactate Accumulation (OBLA) and Performance in Female Runners during the Maximal Treadmill Test.International journal of environmental research and public health · 2021Article
- Effects of Pre-, Post- and Intra-Exercise Hyperbaric Oxygen Therapy on Performance and Recovery: A Systematic Review and Meta-Analysis.Frontiers in physiology · 2021Article
- The Effects of Hyperoxia on Sea-Level Exercise Performance, Training, and Recovery: A Meta-Analysis.Sports medicine (Auckland, N.Z.) · 2018Review
- Hyper-Oxygenation Attenuates the Rapid Vasodilatory Response to Muscle Contraction and Compression.Frontiers in physiology · 2018Article
- The Impact of Hyperoxia on Human Performance and Recovery.Sports medicine (Auckland, N.Z.) · 2017Review
- Effects of Exercise Training under Hyperbaric Oxygen on Oxidative Stress Markers and Endurance Performance in Young Soccer Players: A Pilot Study.Journal of nutrition and metabolism · 2016Article
- Regulation of increased blood flow (hyperemia) to muscles during exercise: a hierarchy of competing physiological needs.Physiological reviews · 2015Review
- Muscle blood flow, hypoxia, and hypoperfusion.Journal of applied physiology (Bethesda, Md. : 1985) · 2014Review
- Haemodynamic responses to dehydration in the resting and exercising human leg.European journal of applied physiology · 2013Article
- Skeletal muscle vasodilatation during maximal exercise in health and disease.The Journal of physiology · 2012Review
- Local control of skeletal muscle blood flow during exercise: influence of available oxygen.Journal of applied physiology (Bethesda, Md. : 1985) · 2011Review
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hypoxia during exercise augments blood flow in active muscles to maintain the delivery of O(2) at normoxic levels. However, the impact of hyperoxia on skeletal muscle blood flow during exercise is not completely understood. Therefore, we tested the hypothesis that the hyperemic response to forearm exercise during hyperbaric hyperoxia would be blunted compared with exercise during normoxia. Seven subjects (6 men/1 woman; 25 ± 1 yr) performed forearm exercise (20% of maximum) under normoxic and hyperoxic conditions. Forearm blood flow (FBF; in ml/min) was measured using Doppler ultrasound. Forearm vascular conductance (FVC; in ml·min(-1)·100 mmHg(-1)) was calculated from FBF and blood pressure (in mmHg; brachial arterial catheter). Studies were performed in a hyperbaric chamber with the subjects supine at 1 atmospheres absolute (ATA) (sea level) while breathing normoxic gas [21% O(2), 1 ATA; inspired Po(2) (Pi(O(2))) ≈ 150 mmHg] and at 2.82 ATA while breathing hyperbaric normoxic (7.4% O(2), 2.82 ATA, Pi(O(2)) ≈ 150 mmHg) and hyperoxic (100% O(2), 2.82 ATA, Pi(O(2)) ≈ 2,100 mmHg) gas. Resting FBF and FVC were less during hyperbaric hyperoxia compared with hyperbaric normoxia (P < 0.05). The change in FBF and FVC (Δ from rest) during exercise under normoxia (204 ± 29 ml/min and 229 ± 37 ml·min(-1)·100 mmHg(-1), respectively) and hyperbaric normoxia (203 ± 28 ml/min and 217 ± 35 ml·min(-1)·100 mmHg(-1), respectively) did not differ (P = 0.66-0.99). However, the ΔFBF (166 ± 21 ml/min) and ΔFVC (163 ± 23 ml·min(-1)·100 mmHg(-1)) during hyperbaric hyperoxia were substantially attenuated compared with other conditions (P < 0.01). Our data suggest that exercise hyperemia in skeletal muscle is highly dependent on oxygen availability during hyperoxia.
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