ArticleAmerican journal of physiology. Lung cellular and molecular physiology2011
Caveolin-1 and force regulation in porcine airway smooth muscle.
Article in American journal of physiology. Lung cellular and molecular physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 30 citations in OpenAlex.
- Cigarette smoke enhances proliferation and extracellular matrix deposition by human fetal airway smooth muscle.American journal of physiology. Lung cellular and molecular physiology · 2014Trial
- Brain-derived neurotrophic factor in cigarette smoke-induced airway hyperreactivity.American journal of respiratory cell and molecular biology · 2013Trial
- Polymeric nanoparticle-mediated siRNA delivery into primary human bronchial airway cells.American journal of physiology. Cell physiology · 2026Article
- Mechanisms underlying TNFα-induced enhancement of force generation in airway smooth muscle.Physiological reports · 2019Article
- Caveolin-1 scaffolding domain peptide prevents hyperoxia-induced airway remodeling in a neonatal mouse model.American journal of physiology. Lung cellular and molecular physiology · 2019Article
- Gene expression profiles and signaling mechanisms in αBMC systems biology · 2017Article
- TNFα enhances force generation in airway smooth muscle.American journal of physiology. Lung cellular and molecular physiology · 2017Article
- Moderate hyperoxia induces extracellular matrix remodeling by human fetal airway smooth muscle cells.Pediatric research · 2017Article
- Interaction between endoplasmic/sarcoplasmic reticulum stress (ER/SR stress), mitochondrial signaling and Ca(2+) regulation in airway smooth muscle (ASM).Canadian journal of physiology and pharmacology · 2015Review
- Antigen-induced airway hyperresponsiveness and obstruction is related to caveolin-1 expression in airway smooth muscle in a guinea pig asthma model.Clinical and translational allergy · 2015Article
- Inflammation, caveolae and CD38-mediated calcium regulation in human airway smooth muscle.Biochimica et biophysica acta · 2014Article
- Increased PDE5 activity and decreased Rho kinase and PKC activities in colonic muscle from caveolin-1-/- mice impair the peristaltic reflex and propulsion.American journal of physiology. Gastrointestinal and liver physiology · 2013Article
- Airway hyperresponsiveness is associated with airway remodeling but not inflammation in aging Cav1-/- mice.Respiratory research · 2013Article
- Differential regulation of muscarinic M2 and M3 receptor signaling in gastrointestinal smooth muscle by caveolin-1.American journal of physiology. Cell physiology · 2013Article
- Caveolin-1 knockout mice exhibit airway hyperreactivity.American journal of physiology. Lung cellular and molecular physiology · 2012Article
- Oxygen dose responsiveness of human fetal airway smooth muscle cells.American journal of physiology. Lung cellular and molecular physiology · 2012Article
- Caveolae and propofol effects on airway smooth muscle.British journal of anaesthesia · 2012Article
- Caveolin-1 regulation of store-operated Ca(2+) influx in human airway smooth muscle.The European respiratory journal · 2012Article
- Enhanced phosphorylation of caveolar PKC-α limits peptide internalization in lung endothelial cells.Molecular and cellular biochemistry · 2012Article
- Stimulus-specific activation and actin dependency of distinct, spatially separated ERK1/2 fractions in A7r5 smooth muscle cells.PloS one · 2012Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Caveolae are specialized membrane microdomains expressing the scaffolding protein caveolin-1. We recently demonstrated the presence of caveolae in human airway smooth muscle (ASM) and the contribution of caveolin-1 to intracellular calcium ([Ca(2+)](i)) regulation. In the present study, we tested the hypothesis that caveolin-1 regulates ASM contractility. We examined the role of caveolins in force regulation of porcine ASM under control conditions as well as TNF-α-induced airway inflammation. In porcine ASM strips, exposure to 10 mM methyl-β-cyclodextrin (CD) or 5 μM of the caveolin-1 specific scaffolding domain inhibitor peptide (CSD) resulted in time-dependent decrease in force responses to 1 μM ACh. Overnight exposure to the cytokine TNF-α (50 ng/ml) accelerated and increased caveolin-1 expression and enhanced force responses to ACh. Suppression of caveolin-1 with small interfering RNA mimicked the effects of CD or CSD. Regarding mechanisms by which caveolae contribute to contractile changes, inhibition of MAP kinase with 10 μM PD98059 did not alter control or TNF-α-induced increases in force responses to ACh. However, inhibiting RhoA with 100 μM fasudil or 10 μM Y27632 resulted in significant decreases in force responses, with lesser effects in TNF-α exposed samples. Furthermore, Ca(2+) sensitivity for force generation was substantially reduced by fasudil or Y27632, an effect even more enhanced in the absence of caveolin-1 signaling. Overall, these results indicate that caveolin-1 is a critical player in enhanced ASM contractility with airway inflammation.
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