Evidence map›Paper›PMID 21420479›Full record

ArticleJournal of ethnopharmacology2011

Traditional Medicine Collection Tracking System (TM-CTS): a database for ethnobotanically driven drug-discovery programs.

Eric S J Harris, Sean D Erickson, Andrew N Tolopko, Shugeng Cao, Jane A Craycroft, Robert Scholten, Yanling Fu, Wenquan Wang, Yong Liu, Zhongzhen Zhao and 3 more

Abstract read
In one paragraph

Article in Journal of ethnopharmacology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Eric S J HarrisDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Ave., Boston, MA 02115, USA. eharris@fas.harvard.edu
Sean D Erickson
Andrew N Tolopko
Shugeng Cao
Jane A Craycroft
Robert Scholten
Yanling Fu
Wenquan Wang
Yong Liu
Zhongzhen Zhao
Jon Clardy
Caroline E Shamu
David M Eisenberg

Funding

Project 2 - Effects of Herb Fractions on Cell Function/Regulation:U19CA128534 · NCI · HARVARD MEDICAL SCHOOL · PI CLARDY, JON · 2006 to 2009
$1.8M
NCI NIH HHS U19 CA128534
6 · The paper itself

Abstract

ethnopharmacological relevanceEthnobotanically driven drug-discovery programs include data related to many aspects of the preparation of botanical medicines, from initial plant collection to chemical extraction and fractionation. The Traditional Medicine Collection Tracking System (TM-CTS) was created to organize and store data of this type for an international collaborative project involving the systematic evaluation of commonly used Traditional Chinese Medicinal plants. MATERIALS AND

methodsThe system was developed using domain-driven design techniques, and is implemented using Java, Hibernate, PostgreSQL, Business Intelligence and Reporting Tools (BIRT), and Apache Tomcat.

resultsThe TM-CTS relational database schema contains over 70 data types, comprising over 500 data fields. The system incorporates a number of unique features that are useful in the context of ethnobotanical projects such as support for information about botanical collection, method of processing, quality tests for plants with existing pharmacopoeia standards, chemical extraction and fractionation, and historical uses of the plants. The database also accommodates data provided in multiple languages and integration with a database system built to support high throughput screening based drug discovery efforts. It is accessed via a web-based application that provides extensive, multi-format reporting capabilities.

conclusionsThis new database system was designed to support a project evaluating the bioactivity of Chinese medicinal plants. The software used to create the database is open source, freely available, and could potentially be applied to other ethnobotanically driven natural product collection and drug-discovery programs.

Indexed as

Drug DiscoveryMedicine, TraditionalDatabase Management Systems

Identifiers

PMID21420479
PMCPMC3096074

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.