ArticleDevelopmental biology2011
Osr2 acts downstream of Pax9 and interacts with both Msx1 and Pax9 to pattern the tooth developmental field.
Article in Developmental biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 48 citations in OpenAlex.
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- Decoding dental mesenchymal stem cells diversity: single-cell transcriptomics maps heterogeneity in molar development.Frontiers in cell and developmental biology · 2025Review
- Four NovelInternational journal of molecular sciences · 2022Article
- Genome-Wide Estimates of Runs of Homozygosity, Heterozygosity, and Genetic Load in Two Chinese Indigenous Goat Breeds.Frontiers in genetics · 2022Article
- Crucial Roles of microRNA-16-5p and microRNA-27b-3p in Ameloblast Differentiation Through Regulation of Genes Associated With Amelogenesis Imperfecta.Frontiers in genetics · 2022Article
- Testing the inhibitory cascade model in a recent human sample.Journal of anatomy · 2021Article
- Innovative Molecular and Cellular Therapeutics in Cleft Palate Tissue Engineering.Tissue engineering. Part B, Reviews · 2021Review
- Individual Limb Muscle Bundles Are Formed through Progressive Steps Orchestrated by Adjacent Connective Tissue Cells during Primary Myogenesis.Cell reports · 2020Article
- Gene datasets associated with mouse cleft palate.Data in brief · 2018Article
- Identification of Osr2 Transcriptional Target Genes in Palate Development.Journal of dental research · 2017Article
- Small-molecule Wnt agonists correct cleft palates inDevelopment (Cambridge, England) · 2017Article
- Modulating Wnt Signaling Rescues Palate Morphogenesis in Pax9 Mutant Mice.Journal of dental research · 2017Article
- Anti-EDAR Agonist Antibody Therapy Resolves Palate Defects in Pax9Journal of dental research · 2017Article
- Activin and Bmp4 Signaling Converge on Wnt Activation during Odontogenesis.Journal of dental research · 2017Article
- Golga5 is dispensable for mouse embryonic development and postnatal survival.Genesis (New York, N.Y. : 2000) · 2017Article
- Genetic Basis of Nonsyndromic and Syndromic Tooth Agenesis.Journal of pediatric genetics · 2016Review
- Deletion of Osr2 Partially Rescues Tooth Development in Runx2 Mutant Mice.Journal of dental research · 2015Article
- A comparative examination of odontogenic gene expression in both toothed and toothless amniotes.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2015Article
- Species-specific modifications of mandible shape reveal independent mechanisms for growth and initiation of the coronoid.EvoDevo · 2015Article
- Cellular and Molecular Mechanisms of Palatogenesis.Current topics in developmental biology · 2015Review
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8 authors at 1 institution in 1 country.
Funding
Abstract
Mammalian tooth development depends on activation of odontogenic potential in the presumptive dental mesenchyme by the Msx1 and Pax9 transcription factors. We recently reported that the zinc finger transcription factor Osr2 was expressed in a lingual-to-buccal gradient pattern surrounding the developing mouse molar tooth germs and mice lacking Osr2 developed supernumerary teeth lingual to their molars. We report here generation of a gene-targeted mouse strain that allows conditional inactivation of Pax9 and subsequent activation of expression of Osr2 in the developing tooth mesenchyme from the Pax9 locus. Expression of Osr2 from one copy of the Pax9 gene did not disrupt normal tooth development but was sufficient to suppress supernumerary tooth formation in the Osr2(-/-) mutant mice. We found that endogenous Osr2 mRNA expression was significantly downregulated in the developing tooth mesenchyme in Pax9(del/del) mice. Mice lacking both Osr2 and Pax9 exhibited early tooth developmental arrest with significantly reduced Bmp4 and Msx1 mRNA expression in the developing tooth mesenchyme, similar to that in Pax9(del/del) mutants but in contrast to the rescue of tooth morphogenesis in Msx1(-/-)Osr2(-/-) double mutant mice. Furthermore, we found that Osr2 formed stable protein complexes with the Msx1 protein and interacted weakly with the Pax9 protein in co-transfected cells. These data indicate that Osr2 acts downstream of Pax9 and patterns the mesenchymal odontogenic field through protein-protein interactions with Msx1 and Pax9 during early tooth development.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.