Evidence map›Paper›PMID 21420377›Full record

ReviewActa tropica2012

Malaria in Uganda: challenges to control on the long road to elimination: I. Epidemiology and current control efforts.

Adoke Yeka, Anne Gasasira, Arthur Mpimbaza, Jane Achan, Joaniter Nankabirwa, Sam Nsobya, Sarah G Staedke, Martin J Donnelly, Fred Wabwire-Mangen, Ambrose Talisuna and 3 more

Abstract readReview
In one paragraph

Review in Acta tropica, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 147 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
147citing papers in PubMed, 1 pooled it
13.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

147 citing papers in PubMed, 1 synthesis or guideline pooled it, 222 citations in OpenAlex.

  1. Meta-Analysis of Human Antibodies AgainstFrontiers in immunology · 2022
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  3. Dihydroartemisinin-Piperaquine Chemoprevention and Malaria Incidence After Severe Flooding: Evaluation of a Pragmatic Intervention in Rural Uganda.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2022
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87 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 3 countries.

Adoke YekaInfectious Diseases Research Collaboration, Kampala, Uganda.
Anne Gasasira
Arthur Mpimbaza
Jane Achan
Joaniter Nankabirwa
Sam Nsobya
Sarah G Staedke
Martin J Donnelly
Fred Wabwire-Mangen
Ambrose Talisuna
Grant Dorsey
Moses R Kamya
Philip J Rosenthal
Makerere University · UGInfectious Diseases Research Collaboration · UGLiverpool School of Tropical Medicine · GBLondon School of Hygiene & Tropical Medicine · GBSan Francisco General Hospital · USUniversity of California, San Francisco · US

Funding

Transmission ProjectU19AI089674 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Isaac Ssewanyana · 2010 to 2026
$29.3M
Resistance of Malaria Parasites to Artemisinin-Based TherapiesR01AI075045 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ROSENTHAL, PHILIP JON · 2009 to 2024
$8.4M
Clinical &Molecular Studies of Drug Resistant MalariaU01AI052142 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ROSENTHAL, PHILIP JON · 2003 to 2008
$4.4M
Training In Malaria Research in UgandaD43TW007375 · FIC · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ROSENTHAL, PHILIP JON · 2005 to 2019
$2.9M
FIC NIH HHS D43 TW007375NIAID NIH HHS R01 AI075045NIAID NIH HHS U01 AI052142NIAID NIH HHS U19 AI089674
6 · The paper itself

Abstract

Malaria remains one of the leading health problems of the developing world, and Uganda bears a particularly large burden from the disease. Our understanding is limited by a lack of reliable data, but it is clear that the prevalence of malaria infection, incidence of disease, and mortality from severe malaria all remain very high. Uganda has made progress in implementing key malaria control measures, in particular distribution of insecticide-impregnated bednets, indoor residual spraying of insecticides, utilization of artemisinin-based combination therapy to treat uncomplicated malaria, and provision of intermittent preventive therapy for pregnant women. However, despite enthusiasm regarding the potential for the elimination of malaria in other areas, there is no convincing evidence that the burden of malaria has decreased in Uganda in recent years. Major challenges to malaria control in Uganda include very high malaria transmission intensity, inadequate health care resources, a weak health system, inadequate understanding of malaria epidemiology and the impact of control interventions, increasing resistance of parasites to drugs and of mosquitoes to insecticides, inappropriate case management, inadequate utilization of drugs to prevent malaria, and inadequate epidemic preparedness and response. Despite these challenges, prospects for the control of malaria have improved, and with attention to underlying challenges, progress toward the control of malaria in Uganda can be expected.

Indexed as

AnimalsAntimalarialsCommunicable Disease ControlDelivery of Health CareDisease Transmission, InfectiousDrug ResistanceHumansInsecticidesInsecticide-Treated BednetsInsect VectorsMalariaMosquito ControlPlasmodiumPrevalenceUgandaAntimalarialsInsecticides

Identifiers

PMID21420377
PMCPMC3156969
OpenAlexW1501895899

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.