ArticleBone2011
Understanding in vivo response and mechanical property variation in MgO, SrO and SiO₂ doped β-TCP.
Article in Bone, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
48 citing papers in PubMed, 1 synthesis or guideline pooled it, 154 citations in OpenAlex.
- Unleashing innovation: 3D-printed biomaterials in bone tissue engineering for repairing femur and tibial defects in animal models - a systematic review and meta-analysis.Frontiers in bioengineering and biotechnology · 2024Pooled it
- Evaluation of an angio-osseo inductive bone ceramic versus demineralised freeze-dried bone allograft in the treatment of periodontal intrabony defects: a randomised controlled clinical trial.Biomaterial investigations in dentistry · 2026Article
- Fabrication and Characterization of Highly Porous Gyroid Scaffolds Composed of Deproteinized Bone Mineral.Journal of functional biomaterials · 2025Article
- Strategic incorporation of metal ions in bone regenerative scaffolds: multifunctional platforms for advancing osteogenesis.Regenerative biomaterials · 2025Review
- MgO-enhanced β-TCP promotes osteogenesis in both in vitro and in vivo rat models.Scientific reports · 2024Article
- Smurf1-targeting microRNA-136-5p-modified bone marrow mesenchymal stem cells combined with 3D-printed β-tricalcium phosphate scaffolds strengthen osteogenic activity and alleviate bone defects.The Kaohsiung journal of medical sciences · 2024Article
- Pore graded borosilicate bioactive glass scaffolds: in vitro dissolution and cytocompatibility.Journal of materials science. Materials in medicine · 2024Article
- 3D Printed SiOJournal of medicinal chemistry · 2024Article
- Optimization of a tunable process for rapid production of calcium phosphate microparticles using a droplet-based microfluidic platform.Frontiers in bioengineering and biotechnology · 2024Article
- TCP Doped with Metal Ions Reinforced with Tetragonal and Cubic Zirconia.Biomimetics (Basel, Switzerland) · 2023Article
- Materials in the NaMaterials (Basel, Switzerland) · 2023Review
- Article
- In vivo biocompatibility of SrO and MgO doped brushite cements.Journal of biomedical materials research. Part B, Applied biomaterials · 2023Article
- Baghdadite: A Novel and Promising Calcium Silicate in Regenerative Dentistry and Medicine.ACS omega · 2022Review
- Mesoporous Bioactive Glasses Incorporated into an Injectable Thermosensitive Hydrogel for Sustained Co-Release of SrPharmaceutics · 2022Article
- Effect of Angiogenesis in Bone Tissue Engineering.Annals of biomedical engineering · 2022Review
- Calcium Phosphate-Coated and Strontium-Incorporated Mesoporous Silica Nanoparticles Can Effectively Induce Osteogenic Stem Cell Differentiation.Advanced healthcare materials · 2022Article
- Three dimensional printed nanostructure biomaterials for bone tissue engineering.Regenerative therapy · 2021Review
- Biodegradable materials for bone defect repair.Military Medical Research · 2020Review
- Crystallization of carboplatin-loaded onto microporous calcium phosphate using high-vacuum method: Characterization and release study.PloS one · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The aim of this work is to evaluate the influence of MgO, SrO and SiO₂ doping on mechanical and biological properties of β-tricalcium phosphate (β-TCP) to achieve controlled resorption kinetics of β-TCP system for maxillofacial and spinal fusion application. We prepared dense TCP compacts of four different compositions, i) pure β-TCP, ii) β-TCP with 1.0wt.% MgO+1.0wt.% SrO, iii) β-TCP with 1.0wt.% SrO+0.5wt.% SiO₂, and iv) β-TCP with 1.0wt.% MgO+1.0wt.% SrO+0.5wt.% SiO₂, by uniaxial pressing and sintering at 1250°C. β phase stability is observed at 1250°C sintering temperature due to MgO doping in β-TCP. In vitro mineralization in simulated body fluid (SBF) for 16 weeks shows excellent apatite growth on undoped and doped samples. Strength degradation of TCP samples in SBF is significantly influenced by both dopant chemistry and amount of dopant. Compressive strengths for all samples show degradation in SBF over the 16 week time period with varying degradation kinetics. MgO/SrO/SiO₂ doped sample shows no strength loss, while undoped TCP shows the maximum strength loss from 419 ± 28 MPa to 158 ± 28 MPa over the 16 week study. In case of MgO/SrO doped TCP, strength loss is slow and gradual. TCP doped with 1.0wt.% MgO and 1.0wt.% SrO shows excellent in vivo biocompatibility when tested in male Sprague-Dawley rats for 16 weeks. Histomorphology analysis reveals that MgO/SrO doped TCP promoted osteogenesis by excellent early stage bone remodeling as compared to undoped TCP.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.