Evidence map›Paper›PMID 21419699›Full record

ReviewTrends in immunology2011

Innate control of B cell responses.

Andrea Cerutti, Irene Puga, Montserrat Cols

Open access · greenAbstract readReview
In one paragraph

Review in Trends in immunology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed
5.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

67 citing papers in PubMed, 100 citations in OpenAlex.

  1. Trial
  2. Interleukin-6 fromMicrobiology spectrum · 2026
    Article
  3. Review
  4. Article
  5. Article
  6. Integration of multiomics analyses reveals unique insights into CD24-mediated immunosuppressive tumor microenvironment of breast cancer.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2024
    Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. The up-to-date pathophysiology of Kawasaki disease.Clinical & translational immunology · 2021
    Review
  15. Review
  16. Article
  17. Review
  18. Article
  19. Review
  20. Article

7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 2 countries.

Andrea CeruttiICREA, Catalan Institute for Research and Advanced Studies, Barcelona Biomedical Research Park, Av. Dr. Aigüader 88, 08003 Barcelona, Spain. acerutti@imim.es
Irene Puga
Montserrat Cols
Icahn School of Medicine at Mount Sinai · USInstitució Catalana de Recerca i Estudis Avançats · ESMunicipal Institute for Medical Research · ES

Funding

Regulation of antibody production by innate signalsR01AI057653 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI CERUTTI, ANDREA · 2005 to 2016
$4.3M
Regulation of antibody diversification and production in HIV-1 infectionR01AI074378 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI CERUTTI, ANDREA · 2008 to 2012
$2.1M
NIAID NIH HHS R01 AI057653NIAID NIH HHS R01 AI-074378NIAID NIH HHS R01 AI074378
6 · The paper itself

Abstract

Mature B cells generate protective immunity by undergoing immunoglobulin (Ig) class switching and somatic hypermutation, two Ig gene-diversifying processes that usually require cognate interactions with T cells that express CD40 ligand. This T cell-dependent pathway provides immunological memory but is relatively slow to occur. Thus, it must be integrated with a faster, T cell-independent pathway for B cell activation through CD40 ligand-like molecules that are released by innate immune cells in response to microbial products. Here, we discuss recent advances in our understanding of the interplay between the innate immune system and B cells, particularly at the mucosal interface. We also review the role of innate signals in the regulation of Ig diversification and production.

Indexed as

Immunity, InnateB-Cell Activating FactorB-LymphocytesGene Expression RegulationGenes, ImmunoglobulinLigandsT-LymphocytesToll-Like ReceptorsTumor Necrosis Factor Ligand Superfamily Member 13B-Cell Activating FactorLigandsTNFSF13B protein, humanToll-Like ReceptorsTumor Necrosis Factor Ligand Superfamily Member 13

Identifiers

PMID21419699
PMCPMC3090458
OpenAlexW2078318266

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.