ArticleEpidemiology and infection2012
Optimal design of studies of influenza transmission in households. I: case-ascertained studies.
Article in Epidemiology and infection, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The Asymptomatic Proportion of SARS-CoV-2 Omicron Variant Infections in Households: A Systematic Review.Influenza and other respiratory viruses · 2024Pooled it
- Household transmission of 2009 pandemic influenza A (H1N1): a systematic review and meta-analysis.Epidemiology (Cambridge, Mass.) · 2012Pooled it
- Inferring influenza dynamics and control in households.Proceedings of the National Academy of Sciences of the United States of America · 2015Trial
- Estimating influenza transmission parameters: Comparing two study designs, 2023-2024.Epidemics · 2026Article
- Estimated Effectiveness of Influenza Vaccines in Preventing Secondary Infections in Households.JAMA network open · 2024Article
- The role of asymptomatic infections in influenza transmission: what do we really know.The Lancet. Infectious diseases · 2024Review
- Retrospective, Observational Studies for Estimating Vaccine Effects on the Secondary Attack Rate of SARS-CoV-2.American journal of epidemiology · 2023Observational
- Transmissibility and transmission of respiratory viruses.Nature reviews. Microbiology · 2021Review
- SARS-CoV-2 Transmissibility Within Day Care Centers-Study Protocol of a Prospective Analysis of Outbreaks in Germany.Frontiers in public health · 2021Article
- Transmission of respiratory and gastrointestinal infections in German households with children attending child care.Epidemiology and infection · 2018Article
- Effects of pathogen dependency in a multi-pathogen infectious disease system including population level heterogeneity - a simulation study.Theoretical biology & medical modelling · 2017Article
- Epidemiology and etiology of influenza-like-illness in households in Vietnam; it's not all about the kids!Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2016Article
- Household Transmission of Influenza Virus.Trends in microbiology · 2016Review
- Factors associated with transmission of influenza-like illness in a cohort of households containing multiple children.Influenza and other respiratory viruses · 2015Article
- Comparative community burden and severity of seasonal and pandemic influenza: results of the Flu Watch cohort study.The Lancet. Respiratory medicine · 2014Article
- Pandemic H1N1 virus transmission and shedding dynamics in index case households of a prospective Vietnamese cohort.The Journal of infection · 2014Article
- Optimal design of studies of influenza transmission in households. II: comparison between cohort and case-ascertained studies.Epidemiology and infection · 2014Article
- Household transmission of respiratory viruses - assessment of viral, individual and household characteristics in a population study of healthy Australian adults.BMC infectious diseases · 2012Article
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Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Case-ascertained household transmission studies, in which households including an 'index case' are recruited and followed up, are invaluable to understanding the epidemiology of influenza. We used a simulation approach parameterized with data from household transmission studies to evaluate alternative study designs. We compared studies that relied on self-reported illness in household contacts vs. studies that used home visits to collect swab specimens for virological confirmation of secondary infections, allowing for the trade-off between sample size vs. intensity of follow-up given a fixed budget. For studies estimating the secondary attack proportion, 2-3 follow-up visits with specimens collected from all members regardless of illness were optimal. However, for studies comparing secondary attack proportions between two or more groups, such as controlled intervention studies, designs with reactive home visits following illness reports in contacts were most powerful, while a design with one home visit optimally timed also performed well.
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