ArticleCritical care (London, England)2011
Acquired bloodstream infection in the intensive care unit: incidence and attributable mortality.
Article in Critical care (London, England), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 90 papers, 1 of them a synthesis that pooled it.
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Who cites it
90 citing papers in PubMed, 1 synthesis or guideline pooled it, 218 citations in OpenAlex.
- Procalcitonin for predicting catheter-associated bloodstream infection: A meta-analysis.Medicine · 2019Pooled it
- Seven-Day vs Four-Day Infusion Set Replacement Interval and Catheter-Related Infections.JAMA network open · 2025Trial
- Trial
- Micafungin versus anidulafungin in critically ill patients with invasive candidiasis: a retrospective study.BMC infectious diseases · 2016Trial
- Predictors of Healthcare-Associated Bloodstream Infections in Subjects Hospitalised from the Emergency Department for Non-Infectious Disease.Journal of clinical medicine · 2026Article
- An interpretable machine-learning model for post-admission reassessment of bloodstream infection risk in ICU patients with pneumonia.Scientific reports · 2026Article
- ICU-acquired infection in neutropenic patients.Critical care (London, England) · 2026Article
- Performance of metagenomic next-generation sequencing for bloodstream infections in perioperative critically ill patients- aFrontiers in cellular and infection microbiology · 2026Article
- Long-term outcomes of ICU-acquired infections with a focus on bloodstream infections: a single-center retrospective registry study.Infection · 2025Article
- Exploring the impact of comorbidities and drug resistance on mortality in ICU-acquired bloodstream infections.AMB Express · 2025Article
- Which antimicrobial treatment for patients with bloodstream infection during ECMO support?European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2025Observational
- Selective decontamination regimens in French ICUs: association with reduced infection and resistance emergence.Annals of intensive care · 2025Article
- Risk Factors for Mortality Among Older Adults with Hospital-Acquired Bloodstream Infections in the Intensive Care Unit: A Multicenter Cohort Study.Infectious diseases and therapy · 2025Article
- Personalized machine learning-based prognostic model for ICU-acquired bloodstream infections.Frontiers in cellular and infection microbiology · 2025Article
- The Outcome of Hospital-Acquired Bloodstream Infection and Its Associated Factors in Critical Care Unit.The Malaysian journal of medical sciences : MJMS · 2024Article
- Immunosuppression at ICU admission is not associated with a higher incidence of ICU-acquired bacterial bloodstream infections: the COCONUT study.Annals of intensive care · 2024Article
- Risk factors for bloodstream infection among patients admitted to an intensive care unit of a tertiary hospital of Shanghai, China.Scientific reports · 2024Article
- Predictors of thirty-day mortality among patients with blood stream infection with WHO priority pathogens: single centre exploratory study from a referral teaching hospital in central India.Iranian journal of microbiology · 2024Article
- Article
- Rebound Inverts theAntibiotics (Basel, Switzerland) · 2024Article
30 more citing papers are in PubMed but not listed here.
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionTo estimate the incidence of intensive care unit (ICU)-acquired bloodstream infection (BSI) and its independent effect on hospital mortality.
methodsWe retrospectively studied acquisition of BSI during admissions of >72 hours to adult ICUs from two university-affiliated hospitals. We obtained demographics, illness severity and co-morbidity data from ICU databases and microbiological diagnoses from departmental electronic records. We assessed survival at hospital discharge or at 90 days if still hospitalized.
resultsWe identified 6339 ICU admissions, 330 of which were complicated by BSI (5.2%). Median time to first positive culture was 7 days (IQR 5-12). Overall mortality was 23.5%, 41.2% in patients with BSI and 22.5% in those without. Patients who developed BSI had higher illness severity at ICU admission (median APACHE III score: 79 vs. 68, P < 0.001). After controlling for illness severity and baseline demographics by Cox proportional-hazard model, BSI remained independently associated with risk of death (hazard ratio from diagnosis 2.89; 95% confidence interval 2.41-3.46; P < 0.001). However, only 5% of the deaths in this model could be attributed to acquired-BSI, equivalent to an absolute decrease in survival of 1% of the total population. When analyzed by microbiological classification, Candida, Staphylococcus aureus and gram-negative bacilli infections were independently associated with increased risk of death. In a sub-group analysis intravascular catheter associated BSI remained associated with significant risk of death (hazard ratio 2.64; 95% confidence interval 1.44-4.83; P = 0.002).
conclusionsICU-acquired BSI is associated with greater in-hospital mortality, but complicates only 5% of ICU admissions and its absolute effect on population mortality is limited. These findings have implications for the design and interpretation of clinical trials.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.