ArticleGenetics, selection, evolution : GSE2011
Quantitative trait loci analysis for leg weakness-related traits in a Duroc × Pietrain crossbred population.
Article in Genetics, selection, evolution : GSE, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Unravelling novel and pleiotropic genes for cannon bone circumference and bone mineral density in Yorkshire pigs.Journal of animal science · 2024Pooled it
- Pig Genome Editing for Agriculture: Achievements and Challenges.International journal of molecular sciences · 2025Review
- A combined GWAS approach reveals key loci for socially-affected traits in Yorkshire pigs.Communications biology · 2021Article
- Effect of Cranial Flexion of Pelvic Limbs on Interlaminar Length of the Lumbosacral Space in Sternally and Laterally Recumbent Juvenile Duroc and Adult Yucatan Pigs.Journal of the American Association for Laboratory Animal Science : JAALAS · 2020Article
- Balancing selection at a premature stop mutation in the myostatin gene underlies a recessive leg weakness syndrome in pigs.PLoS genetics · 2019Article
- Identification of mRNAs Related to Tibial Cartilage Development of Yorkshire Piglets.BioMed research international · 2019Article
- Genetic variants of major genes contributing to phosphate and calcium homeostasis and their association with serum parameters in pigs.Journal of applied genetics · 2018Article
- Genome-wide QTL mapping of nine body composition and bone mineral density traits in pigs.Genetics, selection, evolution : GSE · 2014Article
- Whole-genome sequence analysis reveals differences in population management and selection of European low-input pig breeds.BMC genomics · 2014Article
- Emerging genetic basis of osteochondritis dissecans.Clinics in sports medicine · 2014Review
- An f2 pig resource population as a model for genetic studies of obesity and obesity-related diseases in humans: design and genetic parameters.Frontiers in genetics · 2013Article
- Association and expression study of MMP3, TGFβ1 and COL10A1 as candidate genes for leg weakness-related traits in pigs.Molecular biology reports · 2012Article
- Whole genome SNPs discovery in Nero Siciliano pig.Genetics and molecular biologyArticle
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Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLeg weakness issues are a great concern for the pig breeding industry, especially with regard to animal welfare. Traits associated with leg weakness are partly influenced by the genetic background of the animals but the genetic basis of these traits is not yet fully understood. The aim of this study was to identify quantitative trait loci (QTL) affecting leg weakness in pigs.
methodsThree hundred and ten F₂ pigs from a Duroc × Pietrain resource population were genotyped using 82 genetic markers. Front and rear legs and feet scores were based on the standard scoring system. Osteochondrosis lesions were examined histologically at the head and the condylus medialis of the left femur and humerus. Bone mineral density, bone mineral content and bone mineral area were measured in the whole ulna and radius bones using dual energy X-ray absorptiometry. A line-cross model was applied to determine QTL regions associated with leg weakness using the QTL Express software.
resultsEleven QTL affecting leg weakness were identified on eight autosomes. All QTL reached the 5% chromosome-wide significance level. Three QTL were associated with osteochondrosis on the humerus end, two with the fore feet score and two with the rear leg score. QTL on SSC2 and SSC3 influencing bone mineral content and bone mineral density, respectively, reached the 5% genome-wide significance level.
conclusionsOur results confirm previous studies and provide information on new QTL associated with leg weakness in pigs. These results contribute towards a better understanding of the genetic background of leg weakness in pigs.
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