ArticleBMC medical ethics2011
Ethical issues in human genomics research in developing countries.
Article in BMC medical ethics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 90 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
90 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Ethical, social, and cultural issues related to clinical genetic testing and counseling in low- and middle-income countries: a systematic review.Genetics in medicine : official journal of the American College of Medical Genetics · 2021Pooled it
- Imputation-based meta-analysis of severe malaria in three African populations.PLoS genetics · 2013Pooled it
- Research Review: A scoping review exploring the needs, barriers, and facilitators to the collection of biological data in adolescence for mental health research.Journal of child psychology and psychiatry, and allied disciplines · 2026Review
- Ethical Challenges of Obtaining Informed Consent: Qualitative Research on the Perspectives of Tuberculosis Patients Participating in Human Genomic Research in Ethiopia.Developing world bioethics · 2026Article
- Unlocking Ethiopia's genomic landscape and its global significance: a call for inclusive genomics research.Human genomics · 2026Review
- How participation in deliberative engagement affects awareness of, and attitudes towards, genomics research and data sharing: evidence from rural Ghana.BMC medical ethics · 2025Article
- Perspectives of Research Ethics Committees on the Challenges of Human Genomic Research Participation in Ethiopia.Journal of empirical research on human research ethics : JERHRE · 2025Article
- Empowering human research ethics committees to review genomics applications: evaluating the utility of a custom online education resource.European journal of human genetics : EJHG · 2025Article
- Research participants' perception of ethical issues in stroke genomics and neurobiobanking research in Africa.PloS one · 2025Article
- Ethical challenges of conducting and reviewing human genomics research in Malaysia: An exploratory study.Developing world bioethics · 2024Article
- Community engagement conduct for genetics and genomics research: a qualitative study of the experiences and perspectives of key stakeholders in Uganda.BMC medical ethics · 2024Article
- Data sharing ethics toolkit: The Human Cell Atlas.Nature communications · 2024Review
- Ethical considerations for genetic research in low-income countries: perceptions of informed consent, data sharing, and expectations in Nicaragua.European journal of human genetics : EJHG · 2024Article
- Overcoming barriers to single-cell RNA sequencing adoption in low- and middle-income countries.European journal of human genetics : EJHG · 2024Review
- Charting a landmark-driven path forward for population genetics and ancient DNA research in Africa.American journal of human genetics · 2024Review
- Cross-border data sharing for research in Africa: An analysis of the data protection and research ethics requirements in 12 jurisdictions.Research square · 2024Article
- Researchers' Perspectives Regarding Ethical Issues of Biobank Research in the Arab Region.Biopreservation and biobanking · 2024Article
- All you Need is Trust? Public Perspectives on Consenting to Participate in Genomic Research in the Sri Lankan District of Colombo.Asian bioethics review · 2024Article
- Perceptions and beliefs of community gatekeepers about genomic risk information in African cleft research.BMC public health · 2024Article
- Cross-border data sharing through the lens of research ethics committee members in sub-Saharan Africa.PloS one · 2024Article
30 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
backgroundGenome-wide association studies (GWAS) provide a powerful means of identifying genetic variants that play a role in common diseases. Such studies present important ethical challenges. An increasing number of GWAS is taking place in lower income countries and there is a pressing need to identify the particular ethical challenges arising in such contexts. In this paper, we draw upon the experiences of the MalariaGEN Consortium to identify specific ethical issues raised by such research in Africa, Asia and Oceania. DISCUSSION: We explore ethical issues in three key areas: protecting the interests of research participants, regulation of international collaborative genomics research and protecting the interests of scientists in low income countries. With regard to participants, important challenges are raised about community consultation and consent. Genomics research raises ethical and governance issues about sample export and ownership, about the use of archived samples and about the complexity of reviewing such large international projects. In the context of protecting the interests of researchers in low income countries, we discuss aspects of data sharing and capacity building that need to be considered for sustainable and mutually beneficial collaborations. SUMMARY: Many ethical issues are raised when genomics research is conducted on populations that are characterised by lower average income and literacy levels, such as the populations included in MalariaGEN. It is important that such issues are appropriately addressed in such research. Our experience suggests that the ethical issues in genomics research can best be identified, analysed and addressed where ethics is embedded in the design and implementation of such research projects.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.