Trial reportMicrocirculation (New York, N.Y. : 1994)2011
Combined oral contraceptive pills containing desogestrel or drospirenone enhance large vessel and microvasculature vasodilation in healthy premenopausal women.
Trial report in Microcirculation (New York, N.Y. : 1994), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 27 citations in OpenAlex.
- Endothelial function and insulin sensitivity during acute non-esterified fatty acid elevation: Effects of fat composition and gender.Nutrition, metabolism, and cardiovascular diseases : NMCD · 2015Trial
- Consistency of endothelial function across two consecutive oral contraceptive pill cycles.Experimental physiology · 2025Article
- Oral contraceptive pill phase alters mechanisms contributing to cutaneous microvascular function in response to local heating.American journal of physiology. Regulatory, integrative and comparative physiology · 2025Article
- The influence of oral contraceptives on the exercise pressor reflex in the upper and lower body.Physiological reports · 2024Article
- Letter to the Editor in response to: Microvascular endothelial function following the cessation of long-term oral contraceptive pill use: A case report.Experimental physiology · 2023Article
- Associations of Sex Hormones and Hormonal Status With Arterial Stiffness in a Female Sample From Reproductive Years to Menopause.Frontiers in endocrinology · 2021Article
- Sex-specific alterations in blood-borne factors in physically inactive individuals are detrimental to endothelial cell functions.Journal of applied physiology (Bethesda, Md. : 1985) · 2020Article
- Plasma Homoarginine Concentrations According to Use of Hormonal Contraception.Scientific reports · 2018Article
- Hormonal therapy with estradiol and drospirenone improves endothelium-dependent vasodilation in the coronary bed of ovariectomized spontaneously hypertensive rats.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2016Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo determine the effects of different COCs on endothelial function.
backgroundCOCs all contain ethinylestradiol, but different progestins; three of the more common progestins are DSG, LN, and DR. Ethinylestradiol enhances some measures of vascular reactivity, but certain progestins may increase risk of vascular diseases and impair endothelial vasodilation.
methodsTwenty-nine healthy women taking COCs containing 30 μg ethinylestradiol and 150 μg DSG (Marvelon, n = 10), 150 μg LN (Microgynon, n = 10), or 3 mg DR (Yasmin, n = 9) had their vascular reactivity measured using various techniques during their pill-free week (days 5-7) and the third week of active pills (days 26-28). A reference group (n = 10) underwent the same measurements on two consecutive cycles.
resultsFMD and LDI were significantly higher during active-pill visits than pill-free visits in women taking DSG and DR (p < 0.02), but not in women taking LN. There were no differences between the duplicate measures in the reference group.
conclusionsCOCs containing 150 μg DSG or 3 mg DR significantly increase endothelium-dependent vasodilation in both large vessels and peripheral microvasculature. These effects may be due to the progestins exhibiting differential effects on eNOS expression.
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