ArticleTissue engineering. Part A2011
Engineered heart tissue model of diabetic myocardium.
Article in Tissue engineering. Part A, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Modelling Diabetic Cardiomyopathy: Using Human Stem Cell-Derived Cardiomyocytes to Complement Animal Models.Metabolites · 2022Review
- Role of Autophagy in Granulocyte-Colony Stimulating Factor Induced Anti-Apoptotic Effects in Diabetic Cardiomyopathy.Diabetes & metabolism journal · 2021Article
- Zinc protects against cadmium-induced toxicity in neonatal murine engineered cardiac tissues via metallothionein-dependent and independent mechanisms.Acta pharmacologica Sinica · 2020Article
- Human Tissue-Engineered Model of Myocardial Ischemia-Reperfusion Injury.Tissue engineering. Part A · 2019Article
- Three-dimensional microengineered models of human cardiac diseases.Journal of biological engineering · 2019Review
- Article
- Tissue Engineering Approaches in the Design of Healthy and PathologicalFrontiers in bioengineering and biotechnology · 2017Review
- Cardiovascular Organ-on-a-Chip Platforms for Drug Discovery and Development.Applied in vitro toxicology · 2016Review
- Assessment of the Protective Role of Prenatal Zinc versus Insulin Supplementation on Fetal Cardiac Damage Induced by Maternal Diabetes in Rat Using Caspase-3 and KI67 Immunohistochemical Stains.Cardiology research and practice · 2016Article
- PI3K Phosphorylation Is Linked to Improved Electrical Excitability in an In Vitro Engineered Heart Tissue Disease Model System.Tissue engineering. Part A · 2015Article
- Biomaterial based cardiac tissue engineering and its applications.Biomedical materials (Bristol, England) · 2015Review
- Autocrine signaling is a key regulatory element during osteoclastogenesis.Biology open · 2014Article
- Topological and electrical control of cardiac differentiation and assembly.Stem cell research & therapy · 2013Review
- Stem cell-based cardiac tissue engineering.Journal of cardiovascular translational research · 2011Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Myocardial infarction resulting in irreversible loss of cardiomyocytes (CMs) is a leading cause of heart failure. Previously, we reported an in vitro test-bed for screening cell integration between injected test cells and host CM using the engineered heart tissue as a recipient. The objective of this study is to expand our system to diabetic cardiomyopathy conditions. Patients with diabetes show dysfunction of CMs independent of myocardial infarction, indicating that diabetes directly affects CMs. However, the underlying mechanisms are not fully understood, and developing a diabetic CM test-bed could enable drug screening studies specific to the diabetic heart. Diabetic cardiac conditions were mimicked by cultivating neonatal rat CMs seeded onto collagen scaffolds in normal or high glucose with or without insulin. Our results show that high glucose conditions, which mimic diabetic hearts, display poor electrical properties. Gene expression profiles from diabetic, adult, and neonatal rat hearts as well as engineered heart tissues under different conditions were compared. The diabetic rat heart and high glucose conditions increased the ratio of myosin heavy-chain isoform β to α indicative of diseased states; thus, this model system captures some molecular aspects of diabetic cardiomyopathy. Moreover, thiazolidinedione diabetic drug treatment improved electrical excitabilities and exhibited anti-apoptotic effects.
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Registered trials
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