ArticleAnnals of biomedical engineering2011
Mechanical and structural contribution of non-fibrillar matrix in uniaxial tension: a collagen-agarose co-gel model.
Article in Annals of biomedical engineering, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
30 citing papers in PubMed.
- Mechanical cues of an interpenetrating polysaccharide matrix regulate self-assembly of collagen fibers.Science advances · 2026Article
- Developing a protocol to counteract spontaneous in vitro activation of intestinal fibroblasts using design of experiments.npj biomedical innovations · 2026Article
- Developing a Cell Culture Protocol to Induce Quiescence in Intestinal Fibroblasts Using Design of Experiments Statistical Optimization.Research square · 2025Article
- Geophysics-Inspired Nonlinear Stress-Strain Law for Biological Tissues and Its Applications in Compression Optical Coherence Elastography.Materials (Basel, Switzerland) · 2024Article
- Computational and Experimental Characterization of Aligned Collagen across Varied Crosslinking Degrees.Micromachines · 2024Article
- The role of elastin on the mechanical properties of the anterior leaflet in porcine tricuspid valves.PloS one · 2022Article
- Single shot quantitative polarized light imaging system for rapid planar biaxial testing of soft tissues.Frontiers in bioengineering and biotechnology · 2022Article
- Cell-Laden Agarose-Collagen Composite Hydrogels for Mechanotransduction Studies.Frontiers in bioengineering and biotechnology · 2020Article
- Parameters controlling the strength of stochastic fibrous materials.International journal of solids and structures · 2019Article
- Mechanical Response Changes in Porcine Tricuspid Valve Anterior Leaflet Under Osmotic-Induced Swelling.Bioengineering (Basel, Switzerland) · 2019Article
- Poisson's Contraction and Fiber Kinematics in Tissue: Insight From Collagen Network Simulations.Journal of biomechanical engineering · 2018Article
- Functionally Distinct Tendons From Elastin Haploinsufficient Mice Exhibit Mild Stiffening and Tendon-Specific Structural Alteration.Journal of biomechanical engineering · 2017Article
- Inverse poroelasticity as a fundamental mechanism in biomechanics and mechanobiology.Nature communications · 2017Article
- Characterization of Collagen Type I and II Blended Hydrogels for Articular Cartilage Tissue Engineering.Biomacromolecules · 2016Article
- Swelling of Collagen-Hyaluronic Acid Co-Gels: An In Vitro Residual Stress Model.Annals of biomedical engineering · 2016Article
- Tissue Strain Reorganizes Collagen With a Switchlike Response That Regulates Neuronal Extracellular Signal-Regulated Kinase Phosphorylation In Vitro: Implications for Ligamentous Injury and Mechanotransduction.Journal of biomechanical engineering · 2016Article
- Design and Validation of a Vacuum Assisted Anchorage for the Uniaxial Tensile Testing of Soft Materials.Soft materials · 2016Article
- Stretch-induced network reconfiguration of collagen fibres in the human facet capsular ligament.Journal of the Royal Society, Interface · 2016Article
- Quantitative imaging of enzymatic vitreolysis-induced fiber remodeling.Investigative ophthalmology & visual science · 2014Article
- Review of collagen I hydrogels for bioengineered tissue microenvironments: characterization of mechanics, structure, and transport.Tissue engineering. Part B, Reviews · 2014Review
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
The mechanical role of non-fibrillar matrix and the nature of its interaction with the collagen network in soft tissues remain poorly understood, in part because of the lack of a simple experimental model system to quantify these interactions. This study's objective was to examine mechanical and structural properties of collagen-agarose co-gels, utilized as a simplified model system, to understand better the relationships between the collagen network and non-fibrillar matrix. We hypothesized that the presence of agarose would have a pronounced effect on microstructural reorganization and mechanical behavior. Samples fabricated from gel solutions containing 1.0 mg/mL collagen and 0, 0.125, or 0.25% w/v agarose were evaluated via scanning electron microscopy, incremental tensile stress-relaxation tests, and polarized light imaging. While the incorporation of agarose did not dramatically alter collagen network morphology, agarose led to concentration-dependent changes in mechanical and structural properties. Specifically, resistance of co-gels to volume change corresponded with differences in fiber reorientation and elastic/viscoelastic mechanics. Results demonstrate strong relationships between tissue properties and offer insight into behavior of tissues of varying Poisson's ratio and fiber kinematics. Results also suggest that non-fibrillar material may have significant effects on properties of artificial and native tissues even in tension, which is generally assumed to be collagen dominated.
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Registered trials
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