Evidence map›Paper›PMID 21416272›Full record

ArticleJournal of molecular neuroscience : MN2011

The triplet puzzle of homologies in receptor heteromers exists also in other types of protein-protein interactions.

Alexander O Tarakanov, Kjell G Fuxe

Abstract read
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In one paragraph

Article in Journal of molecular neuroscience : MN, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Moonlighting proteins and protein-protein interactions as neurotherapeutic targets in the G protein-coupled receptor field.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2014
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Alexander O TarakanovSt. Petersburg Institute for Informatics and Automation, Russian Academy of Sciences. tar@iias.spb.su
Kjell G Fuxe
Karolinska Institutet · SESt. Petersburg Institute for Informatics and Automation · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Based on our theory, we point out main triplets of amino acid residues in the GABAB1 receptor, found in the central and peripheral nervous system, which seem to be critical for both receptor heterodimerization and chemokine binding. The obtained results suggest that these triplets may "guide-and-clasp" protein-protein interactions playing a role, e.g., in neuroinflammation disorders.

Indexed as

Amino Acid MotifsProtein MultimerizationAnimalsHumansModels, MolecularMolecular Sequence DataProtein BindingProtein Interaction Domains and MotifsProtein IsoformsReceptors, GABA-BSequence AlignmentProtein IsoformsReceptors, GABA-B

Identifiers

PMID21416272
OpenAlexW2018632170

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.