SynthesisJournal of comparative physiology. B, Biochemical, systemic, and environmental physiology2011
A meta-analysis of glucocorticoids as modulators of oxidative stress in vertebrates.
Synthesis in Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01707719 (Isolated Erythrocyte Membrane Susceptibility to Photo-oxidative Stress in Patients Affected by Alzheimer's Disease and Healthy Controls), which is not on this map. Cited by 149 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Isolated Erythrocyte Membrane Susceptibility to Photo-oxidative Stress in Patients Affected by Alzheimer's Disease and Healthy Controls
Who cites it
149 citing papers in PubMed, 1 synthesis or guideline pooled it, 413 citations in OpenAlex.
- Pooled it
- When Does Stress Build Strength? Linking Stress Physiology to Resilience in the Age of Rapid Environmental Change.BioEssays : news and reviews in molecular, cellular and developmental biology · 2026Review
- Accelerated brain aging in Veterans with posttraumatic stress symptoms and mild traumatic brain injury.Neuroimage. Reports · 2026Article
- The aging paradox of Cushing's syndrome: Stress without clear senescence?Journal of neuroendocrinology · 2026Review
- A Twin Study on the Relation Between Positive Mental Health and Biological Aging.International journal of molecular sciences · 2026Article
- State-Dependent and Social Modulation of Circulating Glucocorticoids in a Nomadic Songbird, the Red Crossbill (Integrative organismal biology (Oxford, England) · 2026Article
- The Glucocorticoid Receptor Inhibits NRF2-Mediated Expression of SLC7A11.Free radical biology & medicine · 2025Article
- Telomere-Related Gene Networks in the Ovary Shift Across Environmental Factors.Journal of experimental zoology. Part A, Ecological and integrative physiology · 2025Article
- Clinical Evaluation of Oxidative Stress Markers in Patients with Long COVID During the Omicron Phase in Japan.Antioxidants (Basel, Switzerland) · 2025Article
- Prenatal conditions do not affect brain physiology and learning in a lizard.The Journal of experimental biology · 2025Article
- Plumage polymorphism in the black sparrowhawk (Accipiter melanoleucus) is strongly associated with the expression level of agouti signaling protein.The Journal of heredity · 2025Article
- Assessment of Oxidative Stress and Associated Biomarkers in Wild Avian Species.Animals : an open access journal from MDPI · 2025Review
- Malondialdehyde (MDA) and 8-hydroxy-2'-deoxyguanosine (8-OHdG) levels in canine serum: establishing reference intervals and influencing factors.BMC veterinary research · 2025Article
- Jieduquyuziyin prescription attenuates the side effect of prednisone through regulating gut microbiota when in the combination with prednisone treat MRL/lpr mice.Journal of traditional and complementary medicine · 2025Article
- Short- and long-wavelength lights disrupt endocrine signalling but not immune function in a nocturnal marsupial.Conservation physiology · 2025Article
- Activation of the sympathetic-adrenal-medullary system increases DNA damage during the transition to captivity.Integrative organismal biology (Oxford, England) · 2025Article
- Serum total antioxidant status in dogs: Reference intervals and influence of multiple biological and analytical factors.Veterinary clinical pathology · 2024Article
- Ionizing radiation has negligible effects on the age, telomere length and corticosterone levels of Chornobyl tree frogs.Biology letters · 2024Article
- Association of Preoperative Opioid and Glucocorticoid Use With Mortality and Complication After Total Knee or Hip Arthroplasty.Journal of Korean medical science · 2024Article
- Early Life Stress Influences Oxidative Stress Enzyme Activities in Liver, Heart, Kidney, Suprarenal Glands, and Pancreas in Male and Female Rat Pups.Antioxidants (Basel, Switzerland) · 2024Article
89 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Prolonged high secretion of glucocorticoids normally reflects a state of chronic stress, which has been associated with an increase in disease susceptibility and reduction in Darwinian fitness. Here, we hypothesize that an increase in oxidative stress accounts for the detrimental effects of prolonged high secretion of glucocorticoids. We performed a meta-analysis on studies where physiological stress was induced by administration of glucocorticoids to evaluate the magnitude of their effects on oxidative stress. Glucocorticoids have a significant effect on oxidative stress (Pearson r = 0.552), although this effect depends on the duration of treatment, and is larger in long-term experiments. Importantly, there was a significant effect on tissue, with brain and heart being the most and the least susceptible to GC-induced oxidative stress, respectively. Furthermore, effect size was larger (1) in studies using both sexes compared to males only, (2) when corticosterone rather than dexamethasone was administered and (3) in juveniles than in adults. These effects were not confounded by species, biochemical biomarker, or whether wild or laboratory animals were studied. In conclusion, our meta-analysis suggests that GC-induced oxidative stress could be a further mechanism underlying increases in disease susceptibility and decreases in Darwinian fitness observed under chronic stress.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.