Trial reportPsychopharmacology2011
Tobacco withdrawal components and their relations with cessation success.
Trial report in Psychopharmacology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 87 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
87 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- Association of Drug Cues and Craving With Drug Use and Relapse: A Systematic Review and Meta-analysis.JAMA psychiatry · 2022Pooled it
- Cessation classification likelihood increases with higher expired-air carbon monoxide cutoffs: a meta-analysis.Drug and alcohol dependence · 2021Pooled it
- Antidepressants for smoking cessation.The Cochrane database of systematic reviews · 2020Pooled it
- Compliance with ecological momentary assessment protocols in substance users: a meta-analysis.Addiction (Abingdon, England) · 2019Pooled it
- Antidepressants for smoking cessation.The Cochrane database of systematic reviews · 2014Pooled it
- A systematic review of the relationships between craving and smoking cessation.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2013Pooled it
- Mobile Health Technology for Personalized Tobacco Cessation Support in Laos (Project Support Laos): Protocol for a Randomized Controlled Trial.JMIR research protocols · 2026Trial
- Associations between morning affect and later-day smoking urges and behavior.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2024Trial
- Time-Varying Mediation of Pharmacological Smoking Cessation Treatments on Smoking Lapse via Craving, Cessation Fatigue, and Negative Mood.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2022Trial
- Time-varying effects of 'optimized smoking treatment' on craving, negative affect and anhedonia.Addiction (Abingdon, England) · 2021Trial
- Predictors of Smoking Cessation Attempts and Success Following Motivation-Phase Interventions Among People Initially Unwilling to Quit Smoking.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2020Trial
- Playing Around with Quitting Smoking: A Randomized Pilot Trial of Mobile Games as a Craving Response Strategy.Games for health journal · 2020Trial
- Evaluating the temporal relationships between withdrawal symptoms and smoking relapse.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2019Trial
- Lack of effect of transcranial direct current stimulation (tDCS) on short-term smoking cessation: Results of a randomized, sham-controlled clinical trial.Drug and alcohol dependence · 2019Trial
- Anhedonia: Its Dynamic Relations With Craving, Negative Affect, and Treatment During a Quit Smoking Attempt.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2017Trial
- What a difference a day makes: differences in initial abstinence response during a smoking cessation attempt.Addiction (Abingdon, England) · 2017Trial
- Toward precision smoking cessation treatment II: Proximal effects of smoking cessation intervention components on putative mechanisms of action.Drug and alcohol dependence · 2017Trial
- Differential Efficacy of Nicotine Replacement Among Overweight and Obese Women Smokers.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2015Trial
- Anhedonia as a component of the tobacco withdrawal syndrome.Journal of abnormal psychology · 2015Trial
- Advancing the understanding of craving during smoking cessation attempts: a demonstration of the time-varying effect model.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2014Trial
27 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
rationaleTobacco withdrawal is a key factor in smoking relapse, but important questions about the withdrawal phenomenon remain.
objectivesThis research was intended to provide information about two core components of withdrawal (negative affect and craving): (1) how various withdrawal symptom profile dimensions (e.g., mean level, volatility, extreme values) differ between negative affect and craving; and (2) how these dimensions relate to cessation outcome.
methodsAdult smokers (N = 1,504) in a double-blind randomized placebo-controlled smoking cessation trial provided real-time withdrawal symptom data four times per day for 4 weeks (2 weeks pre-quit and 2 weeks post-quit) via palmtop computers. Cessation outcome was biochemically confirmed 8-week point-prevalence abstinence.
resultsExamination of craving and negative affect dimensions following a cessation attempt revealed that craving symptoms differed from negative affect symptoms, with higher means, greater variability, and a greater incidence of extreme peaks. Regression analyses revealed that abstinence was associated with lower mean levels of both craving and negative affect and fewer incidences of extreme craving peaks. In a multivariate model, the increase in mean craving and negative affect scores each uniquely predicted relapse.
conclusionsReal-time reports revealed different patterns of abstinence-related negative affect and craving and that dimensions of both predict cessation outcome, suggesting that negative affect and craving dimensions each has motivational significance. This underscores the complexity of withdrawal as a determinant of relapse and the need to measure its distinct components and dimensions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.