ArticleJournal of natural medicines2011
Protective effect of Justicia gendarussa Burm.f. on carrageenan-induced inflammation.
Article in Journal of natural medicines, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed, 20 citations in OpenAlex.
- A Discovery in Compatibility of Traditional Chinese Medicine: Spatholobus suberectus Dunn Suppresses Tripterygium wilfordii Hook. f.-Induced Main Toxicity and Enhances Its Main Efficacy.Chemistry & biodiversity · 2026Article
- Pollination ecology and breeding system of Justicia gendarussa Burm. f. (Acanthaceae): first report of fruit set through supplementary obligatory-xenogamous pollination.Die Naturwissenschaften · 2025Article
- A comprehensive review on anti-inflammatory plants: a mechanistic insight through preclinical and clinical studies.Inflammopharmacology · 2025Review
- Vasculoprotective effects ofJournal of traditional and complementary medicine · 2020Article
- Indonesian herbal medicine prevents hypertension-induced left ventricular hypertrophy by diminishing NADPH oxidase-dependent oxidative stress.Oncotarget · 2017Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The present study focuses on the anti-inflammatory activity of Justicia gendarussa Burm.f. on an acute model of inflammation: the carrageenan-induced paw edema assay. Methanolic extract of J. gendarussa (JRM) roots at a dose of 100 mg/kg significantly inhibited edema formation 5 h after carrageenan induction. JRM inhibited carrageenan-elicited total cycloxygenase activity, 5-lipoxygenase and 15-lipoxygenase activities in blood mononuclear cells of rats, decreased neutrophil infiltration in paw tissue as shown by low myeloperoxidase activity, and also caused a 53% inhibition in cyclooxygenase-2 activity in paw tissue. Purification of JRM by liquid-liquid partitioning yielded an ethyl acetate fraction of JRM that showed interleukin-6 downregulation potential and the ability to inhibit prostaglandin E2 production in vivo. The present investigation provides pharmacological evidence to support the folklore claim that J. gendarussa is an anti-inflammatory agent.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.