ArticleHeart and vessels2012
Relation of cardiovascular risk factors and angina status to obstructive coronary artery disease according to categorical coronary artery calcium score.
Article in Heart and vessels, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 22 citations in OpenAlex.
- Prevalence of Angina Pectoris: An Analysis of the National Health Interview Survey (NHIS) Database.Cureus · 2025Article
- New look at the power of zero coronary artery calcium (CAC) in Asian population: a systemic review and meta-analysis.Cardiovascular diagnosis and therapy · 2024Article
- The Diagnostic and Prognostic Value of Coronary Calcium Scoring in Stable Chest Pain Patients: A Narrative Review.RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin · 2022Review
- The significance of coronary artery calcium score as a predictor of coronary artery stenosis in individuals referred for CT angiography.Journal of cardiovascular and thoracic research · 2020Article
- Relationship between aerobic fitness and progression of coronary atherosclerosis.Heart and vessels · 2016Article
- Development of new risk score for pre-test probability of obstructive coronary artery disease based on coronary CT angiography.Heart and vessels · 2015Article
- Evaluation of coronary artery disease and cardiac morphology and function in patients with hypertrophic cardiomyopathy, using cardiac computed tomography.Heart and vessels · 2015Article
- Characteristics of plaque progression detected by serial coronary computed tomography angiography.Heart and vessels · 2014Article
- Reduction of inorganic phosphate-induced human smooth muscle cells calcification by inhibition of protein kinase A and p38 mitogen-activated protein kinase.Heart and vessels · 2014Article
- Dual-source computed tomography coronary angiography in patients with high heart rate.Heart and vessels · 2014Article
- Article
- What is the optimal cut-off point for low coronary artery calcium score assessed by computed tomography? Multi-Detector Computed Tomography ANIN Registry.Postepy w kardiologii interwencyjnej = Advances in interventional cardiology · 2013Article
- Association of midregional proadrenomedullin with coronary artery stenoses, soft atherosclerotic plaques and coronary artery calcium.Heart and vessels · 2012Article
- Characteristics Detected on Computed Tomography Angiography Predict Coronary Artery Plaque Progression in Non-Culprit Lesions.Korean journal of radiologyArticle
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Coronary artery calcium (CAC) is associated with the presence of coronary artery disease (CAD) and cardiovascular risk factors. However, the relation between cardiovascular risk factors and CAD has not yet been fully elucidated in patients with a zero or low coronary artery calcium score (CACS). The purpose of this study was to evaluate the relation of cardiovascular risk factors and angina status to obstructive CAD according to categorical CACS. A total of 753 patients were enrolled in this study. CAC scoring and coronary computed tomographic angiography (CCTA) were performed with dual-source 64-slice CT scanners. The number of patients with a CACS ≤10 and ≤100 were 358 and 528, respectively. Patients with a higher CACS were older and more frequently male, and had a greater frequency of hypertension, diabetes, and hypercholesterolemia. The prevalence of obstructive CAD increased with the CACS. Among patients with a CACS ≤100, age, male gender, diabetes, hypercholesterolemia, and typical angina pectoris were related to obstructive CAD. The presence of hypercholesterolemia was relatively strongly associated with obstructive CAD (OR 6.67, 95% CI 2.91-15.3, p < 0.001) on multivariate analysis. Among patients with a CACS ≤10, men, hypercholesterolemia, and typical angina pectoris were significantly more frequent in patients with than in those without obstructive CAD (p < 0.01). Our data suggest that neither the absence nor low of coronary calcium burden may reliably exclude obstructive CAD in typical symptomatic male patients with hypercholesterolemia. This result may be useful to interpret the relation of CACS to obstructive CAD.
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