ArticleHeart and vessels2012
Development of a model for prediction of coronary atherosclerotic regression: evaluation of high-density lipoprotein cholesterol level and peripheral blood monocyte count.
Article in Heart and vessels, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Contribution of apolipoprotein A-I to the reduction in high-sensitivity C-reactive protein levels by different statins: comparative study of pitavastatin and atorvastatin.Heart and vessels · 2015Trial
- Remodeling pattern is related to the degree of coronary plaque regression induced by pitavastatin: a sub-analysis of the TOGETHAR trial with intravascular ultrasound and coronary angioscopy.Heart and vessels · 2015Trial
- Impacts of age on coronary atherosclerosis and vascular response to statin therapy.Heart and vessels · 2014Trial
- Comparative the predictive value of neutrophil-to-HDL ratio and monocyte-to-HDL ratio for early neurological deterioration in acute ischemic stroke patients following intravenous thrombolysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Article
- Inflammation-related indices and low physical performance in older adults with unintentional weight loss: a cross-sectional study.BMC geriatrics · 2026Article
- Identifying pathways to cardiovascular mortality by causal graphical models and mediation analysis among hypertensive patients: insights from a prospective study.Journal of translational medicine · 2025Article
- SII, SIRI, and MHR as Additional Readings for Personalized Evaluation of Chronic Heart Failure Severity.International journal of molecular sciences · 2025Article
- Independent and joint associations of monocyte to high-density lipoprotein-cholesterol ratio and body mass index with cardiorenal syndrome: insights from NHANES 2003-2020.Lipids in health and disease · 2024Article
- Which Biomarker(s) Augment the Diagnostic Value of the Positive Exercise Electrocardiography Test: Systemic Inflammatory Index, Plasma Atherogenic Index, or Monocyte/HDL-C Ratio?Journal of clinical medicine · 2023Article
- Monocyte to high-density lipoprotein ratio is associated with mortality in patients with coronary artery diseases.BMC cardiovascular disorders · 2023Article
- Association between monocyte to high-density lipoprotein cholesterol ratio and multi-vessel coronary artery disease: a cross-sectional study.Lipids in health and disease · 2023Article
- Assessment of the Prognostic Value of Monocyte-to-HDL Ratio in ST-Elevation Myocardial Infarction Patients Undergoing Primary Percutaneous Coronary Intervention.Galen medical journal · 2023Article
- High ratio of monocytes to high-density lipoprotein is associated with hemorrhagic transformation in acute ischemic stroke patients on intravenous thrombolysis.Frontiers in aging neuroscience · 2022Article
- Serum 25-Hydroxyvitamin D Is Inversely Associated with Monocyte Percentage to HDL Cholesterol Ratio among Young Healthy Adults in Qatar.Nutrients · 2020Article
- The role of monocytosis and neutrophilia in atherosclerosis.Journal of cellular and molecular medicine · 2018Review
- A Novel Marker of Impaired Aortic Elasticity in Never Treated Hypertensive Patients: Monocyte/High-Density Lipoprotein Cholesterol Ratio.Acta Cardiologica Sinica · 2017Article
- Article
- The expression of p66shc in peripheral blood monocytes is increased in patients with coronary heart disease and correlated with endothelium-dependent vasodilatation.Heart and vessels · 2015Article
- Effect of the Kv1.3 voltage-gated potassium channel blocker PAP-1 on the initiation and progress of atherosclerosis in a rat model.Heart and vessels · 2015Article
- Characterization of the effect of serum bilirubin concentrations on coronary endothelial function via measurement of high-sensitivity C-reactive protein and high-density lipoprotein cholesterol.Heart and vessels · 2013Article
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Authors and funding
12 authors.
Funding
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Abstract
Monocytes and high-density lipoprotein cholesterol (HDL-C) play important roles in the process of coronary atherosclerosis. We hypothesized that a reasonable predictive model of coronary plaque regression might be constructed using the change in the peripheral monocyte count and the serum HDL-C level. The plaque volume, as assessed by volumetric intravascular ultrasound, was measured at the baseline and after 6 months of pravastatin therapy in 114 patients with coronary artery disease. After 6 months of pravastatin therapy, a significant decrease of the plaque volume by 9.9% (p < 0.0001, vs. baseline) was observed; furthermore, a corresponding increase of the serum HDL-C level and decrease of the peripheral blood monocyte count were also seen (12.5%, p < 0.01 and -7.3%, p < 0.0001). In a multivariate regression analysis using the serum lipids and traditional risk factors as the covariates, the increase in the serum HDL-C (β -0.56, p < 0.0001) and the decrease in monocyte count (β 0.23, p = 0.03) were identified as independent predictors of the plaque regression. A model for the prediction of plaque regression according to whether the achieved the change in (Δ) monocyte count and ΔHDL-C were above or below the median values was prepared. Among the four groups, the group with ΔHDL-C ≥8.8% and Δmonocyte count ≤-8.6% showed the largest plaque regression (-20.4%), and the group with ΔHDL-C <8.8% and Δmonocyte count >-8.6% showed the increase of the plaque volume (2.6%). In view of the inflammatory nature of atherosclerosis, the model constructed using the two predictors may be a useful model for the prediction of plaque regression.
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