ArticleHeart and vessels2012
Platelet and monocyte activity markers and mediators of inflammation in Takotsubo cardiomyopathy.
Article in Heart and vessels, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- International Expert Consensus Document on Takotsubo Syndrome (Part II): Diagnostic Workup, Outcome, and Management.European heart journal · 2018Guideline
- Platelet function in Takotsubo cardiomyopathy.Journal of thrombosis and thrombolysis · 2015Trial
- Oxidative Stress in Takotsubo Syndrome: Insights into Extracellular Vesicles and Their Potential Clinical Relevance.Antioxidants (Basel, Switzerland) · 2026Review
- Long-Term Prognosis, Risk Assessment, and Management of Patients Diagnosed with Takotsubo Syndrome: A Narrative Review.Journal of personalized medicine · 2025Review
- The Evolving Features of Takotsubo Syndrome.Current cardiology reports · 2025Review
- The Immunology of Takotsubo Syndrome.Frontiers in immunology · 2023Review
- The Heart Is at Risk: Understanding Stroke-Heart-Brain Interactions with Focus on Neurogenic Stress Cardiomyopathy-A Review.Journal of stroke · 2023Review
- Takotsubo Syndrome: Translational Implications and Pathomechanisms.International journal of molecular sciences · 2022Review
- Effect of aspirin in takotsubo syndrome: protocol of a systematic review and meta-analysis.BMJ open · 2021Article
- A systematic review of biomarkers in Takotsubo syndrome: A focus on better understanding the pathophysiology.International journal of cardiology. Heart & vasculature · 2021Review
- Current Knowledge and Future Challenges in Takotsubo Syndrome: Part 1-Pathophysiology and Diagnosis.Journal of clinical medicine · 2021Review
- Neutrophil/lymphocyte ratio predicts in-hospital complications in Takotsubo syndrome. Results from a prospective multi-center registry.Clinical cardiology · 2020Article
- The Great Myocardial Mimic - Takotsubo Syndrome.Maedica · 2020Article
- Elevation of Platelet and Monocyte Activity Markers of Atherosclerosis in Haemodialysis Patients Compared to Peritoneal Dialysis Patients.Mediators of inflammation · 2017Article
- Antiplatelet therapy in Takotsubo cardiomyopathy: does it improve cardiovascular outcomes during index event?Heart and vessels · 2016Article
- "Ballooning" patterns in takotsubo cardiomyopathy reflect different clinical backgrounds and outcomes: a BOREAS-TCM study.Heart and vessels · 2015Article
- Insular infarct size but not levosimendan influenced myocardial injury triggered by cerebral ischemia in rats.Experimental brain research · 2015Article
- Endomyocardial biopsy in a patient with hemorrhagic pheochromocytoma presenting as inverted Takotsubo cardiomyopathy.Heart and vessels · 2013Article
- Acute coronary syndrome or apical ballooning syndrome?Heart and vessels · 2013Article
- Incidence and predictors of stroke during the index event in an ethnically diverse Takotsubo cardiomyopathy population.Functional neurologyArticle
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Patients with Takotsubo cardiomyopathy (TC) often present with symptoms similar to those of myocardial infarction (MI). We analyzed blood concentrations of mediators of inflammation and platelet- and monocyte-activity markers in patients with TC and MI for significant differences. Clinical data of patients with TC (n = 16) and acute MI (n = 16) were obtained. Serial blood samples were taken at the time of hospital admission (t(0)), after 2-4 days (t(1)) and after 4-7 weeks (t(2)), respectively. Plasma concentrations of interleukin (IL)-6, IL-7, soluble CD40 ligand (sCD40L), and monocyte chemotactic protein 1 (MCP-1) were determined with an ELISA. Tissue factor binding on monocytes, platelet-activation marker CD62P, platelet CD40-ligand (CD40L), and platelet-monocyte aggregates were measured using flow cytometry. Expression of CD62P on platelets and IL-6 plasma levels were significantly lower in patients with TC compared to MI at the time of hospital admission. IL-7 plasma levels were significantly elevated in patients with TC compared to patients with MI at 2-4 days after hospital admission. No significant differences were observed concerning sCD40L and MCP-1 plasma levels, tissue factor binding on monocytes, CD40L expression on platelets, and platelet-monocyte aggregates at any point in time. Our results indicate that inflammatory mediators and platelet-activity markers contribute to the differences in the pathogenesis of MI and TC.
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