ArticleAmerican journal of translational research2011
Matrix metalloproteinase activity and glycosaminoglycans in chronic venous disease: the linkage among cell biology, pathology and translational research.
Article in American journal of translational research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 63 citations in OpenAlex.
- Impact of daily cooling treatment on skin inflammation in patients with chronic venous disease.Journal of tissue viability · 2015Trial
- Sulodexide Inhibits Arterial Contraction via the Endothelium-Dependent Nitric Oxide Pathway.Journal of clinical medicine · 2024Article
- Platelets at the Vessel Wall in Non-Thrombotic Disease.Circulation research · 2023Review
- The Structure and Function of the Glycocalyx and Its Connection With Blood-Brain Barrier.Frontiers in cellular neuroscience · 2021Review
- Mechanisms of Lower Extremity Vein Dysfunction in Chronic Venous Disease and Implications in Management of Varicose Veins.Vessel plus · 2021Article
- Endothelial glycocalyx as an important factor in composition of blood-brain barrier.CNS neuroscience & therapeutics · 2021Review
- Why Venous Leg Ulcers Have Difficulty Healing: Overview on Pathophysiology, Clinical Consequences, and Treatment.Journal of clinical medicine · 2020Review
- Article
- Practical context of enzymatic treatment for wound healing: A secreted protease approach (Review).Biomedical reports · 2020Review
- Sulodexide promotes arterial relaxation via endothelium-dependent nitric oxide-mediated pathway.Biochemical pharmacology · 2019Article
- Perioperative implication of the endothelial glycocalyx.Korean journal of anesthesiology · 2018Review
- Melatonin alleviates inflammation-induced apoptosis in human umbilical vein endothelial cells via suppression of CaCell stress & chaperones · 2018Article
- Does cryotherapy improve skin circulation compared with compression and elevation in preventing venous leg ulcers?International wound journal · 2017Article
- Metformin and sulodexide restore cardiac microvascular perfusion capacity in diet-induced obese rats.Cardiovascular diabetology · 2017Article
- Therapeutic Restoration of Endothelial Glycocalyx in Sepsis.The Journal of pharmacology and experimental therapeutics · 2017Article
- From varices to venous ulceration: the story of chronic venous disease described by metalloproteinases.International wound journal · 2017Article
- Weight loss surgery improves the metabolic status in an obese rat model but does not affect bladder fibrosis associated with high fat diet feeding.International journal of obesity (2005) · 2014Article
- Impact of weight loss due to sleeve gastrectomy on shear stress of the femoral vein in morbid obesity.Obesity surgery · 2014Article
- Development and use of sulodexide in vascular diseases: implications for treatment.Drug design, development and therapy · 2013Review
- Matrix metalloproteinases as potential targets in the venous dilation associated with varicose veins.Current drug targets · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Primary chronic venous disease (CVD) is an inflammatory pathology involving an erratic structural remodeling in the venous well leading to vascular incompetence and the development of varicose vein, characterized by altered collagen and elastin content. In the early steps of varicose vein formation is crucial the role of MMP/TIMP balance, implicated in both ECM and vascular degradation during inflammation processes in early and late stages of venous diseases. Although several pharmacological and surgical strategies are being utilized in the management of varicose vein and CVD with variable success and recurrence rate, inhibition of MMP through glycosaminoglycans may represent a novel therapeutic intervention to limit the progression of varicose vein to CVD and leg ulceration, suggesting possible opportunity to prevent future morbidity and enhancing clinical benefits and quality of life.
Indexed as
Identifiers
21416057PMC3056561W160068046What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.