ArticleSoft matter2011
Cell-laden microengineered pullulan methacrylate hydrogels promote cell proliferation and 3D cluster formation.
Article in Soft matter, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed.
- 3D bioprinting of fish skin-based gelatin methacryloyl (GelMA) bio-ink for use as a potential skin substitute.Scientific reports · 2024Article
- Advances in high throughput cell culture technologies for therapeutic screening and biological discovery applications.Bioengineering & translational medicine · 2024Review
- Accelerating Patterned Vascularization Using Granular Hydrogel Scaffolds and Surgical Micropuncture.Small (Weinheim an der Bergstrasse, Germany) · 2024Article
- Perfusion of MC3T3E1 Preosteoblast Spheroids within Polysaccharide-Based Hydrogel Scaffolds: An Experimental and Numerical Study at the Bioreactor Scale.Bioengineering (Basel, Switzerland) · 2023Article
- Engineered biomaterials to guide spheroid formation, function, and fabrication into 3D tissue constructs.Acta biomaterialia · 2023Review
- Super-Macroporous Pulluan Cryogels as Controlled Active Delivery Systems with Controlled Degradability.Micromachines · 2023Article
- Pullulan-Based Hydrogels in Wound Healing and Skin Tissue Engineering Applications: A Review.International journal of molecular sciences · 2023Review
- Current Trends in Biomedical Hydrogels: From Traditional Crosslinking to Plasma-Assisted Synthesis.Polymers · 2022Review
- Bioinspired Hydrogels as Platforms for Life-Science Applications: Challenges and Opportunities.Polymers · 2022Review
- 3D Bioprinting of Cell-Laden Hydrogels for Improved Biological Functionality.Advanced materials (Deerfield Beach, Fla.) · 2022Review
- Development of a New Formulation Based on In Situ Photopolymerized Polymer for the Treatment of Spinal Cord Injury.Polymers · 2021Article
- Glycosaminoglycans in Tissue Engineering: A Review.Biomolecules · 2020Review
- Article
- Biomaterials for Bioprinting Microvasculature.Chemical reviews · 2020Review
- Advancement of Nanobiomaterials to Deliver Natural Compounds for Tissue Engineering Applications.International journal of molecular sciences · 2020Review
- Gelatin-Coated Microfluidic Channels for 3D Microtissue Formation: On-Chip Production and Characterization.Micromachines · 2019Article
- Synthesis and Properties of Gelatin Methacryloyl (GelMA) Hydrogels and Their Recent Applications in Load-Bearing Tissue.Polymers · 2018Review
- Improvement of physico-chemical properties of dextran-chitosan composite scaffolds by addition of nano-hydroxyapatite.Scientific reports · 2018Article
- Atelocollagen-based Hydrogels Crosslinked with Oxidised Polysaccharides as Cell Encapsulation Matrix for Engineered Bioactive Stromal Tissue.Tissue engineering and regenerative medicine · 2017Article
- Precise Tuning of Facile One-Pot Gelatin Methacryloyl (GelMA) Synthesis.Scientific reports · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
The ability to encapsulate cells in three-dimensional (3D) environments is potentially of benefit for tissue engineering and regenerative medicine. In this paper, we introduce pullulan methacrylate (PulMA) as a promising hydrogel platform for creating cell-laden microscale tissues. The hydration and mechanical properties of PulMA were demonstrated to be tunable through modulation of the degree of methacrylation and gel concentration. Cells encapsulated in PulMA exhibited excellent viability. Interestingly, while cells did not elongate in PulMA hydrogels, cells proliferated and organized into clusters, the size of which could be controlled by the hydrogel composition. By mixing with gelatin methacrylate (GelMA), the biological properties of PulMA could be enhanced as demonstrated by cells readily attaching to, proliferating, and elongating within the PulMA/GelMA composite hydrogels. These data suggest that PulMA hydrogels could be useful for creating complex, cell-responsive microtissues, especially for applications that require controlled cell clustering and proliferation.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.