ArticleEMBO reports2011
Ubiquitin-specific protease 4 is inhibited by its ubiquitin-like domain.
Article in EMBO reports, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 43 citations in OpenAlex.
- Research progress of DUB enzyme in breast cancer.Clinical and experimental medicine · 2025Review
- Deubiquitinase USP39 and E3 ligase TRIM26 balance the level of ZEB1 ubiquitination and thereby determine the progression of hepatocellular carcinoma.Cell death and differentiation · 2021Article
- USP15: a review of its implication in immune and inflammatory processes and tumor progression.Genes and immunity · 2021Review
- Deubiquitylation of deubiquitylases.Open biology · 2017Review
- Correction: Chon-Kit Chou, et al. The Regulations of Deubiquitinase USP15 and Its Pathophysiological Mechanisms in Diseases. Int. J. Mol. Sci. 2017, 18, 483.International journal of molecular sciences · 2017Article
- Increased Expression of Ubiquitin-Specific Protease 4 Participates in Neuronal Apoptosis After Intracerebral Hemorrhage in Adult Rats.Cellular and molecular neurobiology · 2017Article
- The Regulations of Deubiquitinase USP15 and Its Pathophysiological Mechanisms in Diseases.International journal of molecular sciences · 2017Review
- MiR-148a suppresses invasion and induces apoptosis of breast cancer cells by regulating USP4 and BIM expression.International journal of clinical and experimental pathology · 2017Article
- Ubiquitin-specific protease 4 inhibits breast cancer cell growth through the upregulation of PDCD4.International journal of molecular medicine · 2016Article
- Recent Advances in the Discovery of Deubiquitinating Enzyme Inhibitors.Progress in medicinal chemistry · 2016Review
- Ubiquitin specific protease 4 positively regulates the WNT/β-catenin signaling in colorectal cancer.Molecular oncology · 2015Article
- Structure and catalytic regulatory function of ubiquitin specific protease 11 N-terminal and ubiquitin-like domains.Biochemistry · 2014Article
- The crystal structure of S. cerevisiae Sad1, a catalytically inactive deubiquitinase that is broadly required for pre-mRNA splicing.RNA (New York, N.Y.) · 2014Article
- The WD40-repeat protein-containing deubiquitinase complex: catalysis, regulation, and potential for therapeutic intervention.Cell biochemistry and biophysics · 2013Review
- Mouse sperm acquire a new structure on the apical hook during epididymal maturation.Asian journal of andrology · 2013Article
- Transient kinetic analysis of USP2-catalyzed deubiquitination reveals a conformational rearrangement in the K48-linked diubiquitin substrate.Biochemistry · 2012Article
- Serine phosphorylation is critical for the activation of ubiquitin-specific protease 1 and its interaction with WD40-repeat protein UAF1.Biochemistry · 2012Article
- Solution structure of the E3 ligase HOIL-1 Ubl domain.Protein science : a publication of the Protein Society · 2012Article
- Review
- Rpn1 and Rpn2 coordinate ubiquitin processing factors at proteasome.The Journal of biological chemistry · 2012Article
Corrections and comments
- Retraction · 2014-01-07Doing the Right Thing · Error in Methods · Results Not Reproducible ·
- Retracted
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
USP4 is a member of the ubiquitin-specific protease (USP) family of deubiquitinating enzymes that has a role in spliceosome regulation. Here, we show that the crystal structure of the minimal catalytic domain of USP4 has the conserved USP-like fold with its typical ubiquitin-binding site. A ubiquitin-like (Ubl) domain inserted into the catalytic domain has autoregulatory function. This Ubl domain can bind to the catalytic domain and compete with the ubiquitin substrate, partially inhibiting USP4 activity against different substrates. Interestingly, other USPs, such as USP39, could relieve this inhibition.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.