ReviewCurrent opinion in organ transplantation2011
Controlling coagulation dysregulation in xenotransplantation.
Review in Current opinion in organ transplantation, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 91 citations in OpenAlex.
- Beyond immune rejection: integrative genetic engineering strategies for overcoming coagulopathy in xenotransplantation.Clinical transplantation and research · 2026Review
- Graft-derived VWF drives platelet activation and thrombocytopenia during porcine liver xenotransplantation to brain-dead human recipients.The Journal of clinical investigation · 2026Article
- Complement system in kidney transplantation: from innate immune surveillance to a therapeutic and genetic engineering target.Frontiers in immunology · 2026Review
- Advancing cardiac xenotransplantation: overcoming challenges and ethical considerations for clinical integration.Frontiers in transplantation · 2026Article
- Revolutionizing medicine: Exploring the breakthroughs in liver xenotransplantation.Liver research (Beijing, China) · 2025Review
- Article
- Addressing glycan and hematological barriers in pig-to-nonhuman primate liver xenotransplantation: challenges and future directions.Clinical transplantation and research · 2025Review
- Characterizing coagulation responses in humans and nonhuman primates following kidney xenotransplantation-A narrative review.American journal of hematology · 2025Review
- Complement, Coagulation, and Fibrinolysis: The Role of the Endothelium and Its Glycocalyx Layer in Xenotransplantation.Transplant international : official journal of the European Society for Organ Transplantation · 2024Review
- Liver Xenotransplantation: A Path to Clinical Reality.Transplant international : official journal of the European Society for Organ Transplantation · 2024Review
- Review
- Cardiac xenotransplantation: a promising way to treat advanced heart failure.Heart failure reviews · 2022Review
- Current Barriers to Clinical Liver Xenotransplantation.Frontiers in immunology · 2022Review
- Interleukin-27 in liver xenotransplantation: A rational target to mitigate ischemia reperfusion injury and increase xenograft survival.Transplantation reviews (Orlando, Fla.) · 2022Review
- The resurgent landscape of xenotransplantation of pig organs in nonhuman primates.Science China. Life sciences · 2021Review
- Tissue-engineered vascular microphysiological platform to study immune modulation of xenograft rejection.Science advances · 2021Article
- The role of human CD46 in early xenoislet engraftment in a dual transplant model.Xenotransplantation · 2019Article
- A review of pig liver xenotransplantation: Current problems and recent progress.Xenotransplantation · 2019Review
- An approach to induction of tolerance to pig cardiac xenografts in neonates.Xenotransplantation · 2018Review
- Physiologic Aspects of Pig Kidney Transplantation in Nonhuman Primates.Comparative medicine · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
Abstract
purpose of reviewDeletion of the α1,3-galactosyltransferase (GalT) gene in pigs has removed a major xenoantigen but has not eliminated the problem of dysregulated coagulation and vascular injury. Rejecting GalT knockout organ xenografts almost invariably show evidence of thrombosis and platelet sequestration, and primate recipients frequently develop consumptive coagulopathy. This review examines recent findings that illuminate potential mechanisms of this current barrier to successful xenotransplantation. RECENT
findingsThe coagulation response to xenotransplantation differs depending on the type of organ and quite likely the distinct vasculatures. Renal xenografts appear more likely to initiate consumptive coagulopathy than cardiac xenografts, possibly reflecting differential transcriptional responses. Liver xenografts induce rapid and profound thrombocytopenia resulting in recipient death within days due to bleeding; ex-vivo data suggest that liver endothelial cells and hepatocytes are responsible for platelet consumption by a coagulation-independent process.It has been proposed that expression of recipient tissue factor on platelets and monocytes is an important trigger of consumptive coagulopathy. Finally, pigs transgenic for human anticoagulants and antithrombotics are slowly but surely coming on line, but have not yet been rigorously tested to date. SUMMARY: Successful control of coagulation dysregulation in xenotransplantation may require different combinatorial pharmacological and genetic strategies for different organs.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.