Evidence map›Paper›PMID 21415495›Full record

ReviewThe Indian journal of medical research2011

The complexity of ToxT-dependent transcription in Vibrio cholerae.

Gregor G Weber, Karl E Klose

Abstract readReview
In one paragraph

Review in The Indian journal of medical research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Article
  2. mBio · 2025
    Article
  3. Article
  4. Article
  5. Review
  6. Small regulatory RNAs inmicroLife · 2023
    Review
  7. Article
  8. Inhibition of α-, β- and γ-carbonic anhydrases from the pathogenic bacteriumJournal of enzyme inhibition and medicinal chemistry · 2021
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Structural basis for virulence regulation inCommunications biology · 2019
    Article
  17. Regulated Proteolysis inFrontiers in cellular and infection microbiology · 2019
    Review
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Gregor G WeberSouth Texas Center for Emerging Infectious Diseases & Department of Biology, University of Texas, San Antonio, San Antonio TX, USA.
Karl E Klose

Funding

Environmental Modulation of ToxT-dependent TranscriptionR01AI051333 · NIAID · UNIVERSITY OF TEXAS SAN ANTONIO · PI KLOSE, KARL E · 2003 to 2007
$1.2M
Environmental Modulation of Toxt-Dependent TranscriptionR56AI051333 · NIAID · UNIVERSITY OF TEXAS SAN ANTONIO · PI KLOSE, KARL E · 2009 to 2009
$289k
NIAID NIH HHS AI51333NIAID NIH HHS R01 AI051333NIAID NIH HHS R56 AI051333
6 · The paper itself

Abstract

Vibrio cholerae is the causative agent of the disease cholera, characterized by profuse watery diarrhoea. Two of the main virulence factors associated with the disease are cholera toxin (CT) and toxin-coregulated pilus (TCP). Expression of CT and TCP is regulated via a complex cascade of factors that respond to environmental signals, but ultimately ToxT is the direct transcriptional activator of the genes encoding CT and TCP. Recent studies have begun to unveil the mechanisms behind ToxT-dependent transcription. We review current knowledge of transcriptional activation by ToxT and the environmental stimuli that allow ToxT to regulate virulence gene expression, resulting in cholera pathogenesis.

Indexed as

Gene Expression Regulation, BacterialTranscription, GeneticBacterial ProteinsBase SequenceCholeraHumansMolecular Sequence DataTranscription FactorsVibrio choleraeBacterial ProteinstcpN protein, Vibrio choleraeTranscription Factors

Identifiers

PMID21415495
PMCPMC3089052

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.