SynthesisStroke2011
Statin treatment and functional outcome after ischemic stroke: case-control and meta-analysis.
Synthesis in Stroke, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 76 citations in OpenAlex.
- Pooled it
- Statins and the incidence of post-stroke depression: a systematic review and meta-analysis.Frontiers in neurology · 2024Pooled it
- Lipid-Lowering Therapy Use When Indicated and Subsequent Ischemic Stroke Severity.Journal of the American Heart Association · 2025Article
- Herb-Drug Interaction Between Sailuotong and Pitavastatin: A Systematic Pharmacokinetic Investigation and Mechanism Analysis.Drug design, development and therapy · 2025Article
- Unsupervised Machine Learning Revealed that Repeat Transcranial Magnetic Stimulation is More Suitable for Stroke Patients with Statin.Neurology and therapy · 2024Article
- Landscape of Statin as a Cornerstone in Atherosclerotic Cardiovascular Disease.Reviews in cardiovascular medicine · 2023Review
- Editorial: Transitional and long-term continuous care & rehabilitation after stroke.Frontiers in neurology · 2022Article
- Pre-Stroke Statin Therapy Improves In-Hospital Prognosis Following Acute Ischemic Stroke Associated with Well-Controlled Nonvalvular Atrial Fibrillation.Journal of clinical medicine · 2021Article
- A Retrospective Study on Statins and Post-stroke Patients: What About Functional Outcome and Follow-Up in a Stroke Rehabilitation Cohort?Frontiers in neurology · 2021Article
- Prestroke statins use reduces oxidized low density lipoprotein levels and improves clinical outcomes in patients with atrial fibrillation related acute ischemic stroke.BMC neurology · 2019Article
- Diabetic patients are at a higher risk of lacunar infarction and dyslipidemia: results of a comparative pilot study from King Fahad Hospital of the University, Saudi Arabia.Neurosciences (Riyadh, Saudi Arabia) · 2017Article
- Differences in the distribution of risk factors for stroke among the high-risk population in urban and rural areas of Eastern China.Brain and behavior · 2016Article
- Austrian Lipid Consensus on the management of metabolic lipid disorders to prevent vascular complications: A joint position statement issued by eight medical societies. 2016 update.Wiener klinische Wochenschrift · 2016Article
- Effect and Safety of Rosuvastatin in Acute Ischemic Stroke.Journal of stroke · 2016Article
- Statins in Acute Ischemic Stroke: A Systematic Review.Journal of stroke · 2015Review
- Effect of pre-stroke statin use on stroke severity and early functional recovery: a retrospective cohort study.BMC neurology · 2015Article
- The effect of statins on National Institutes of Health Stroke Scale (NiHSS) in Ischemic stroke.Journal of medicine and life · 2015Article
- Clinical factors associated with statins prescription in acute ischemic stroke patients: findings from the Lombardia Stroke Registry.BMC neurology · 2014Article
- Association between statin use and short-term outcome based on severity of ischemic stroke: a cohort study.PloS one · 2014Article
- Role of statin in atrial fibrillation-related stroke: an angiographic study for collateral flow.Cerebrovascular diseases (Basel, Switzerland) · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
background and purposeMultiple studies suggest that statin use before acute ischemic stroke is associated with improved functional outcome. However, available evidence is conflicting, and several published reports are limited by small sample sizes. We therefore investigated the effect of antecedent use of statins on stroke outcome by performing a meta-analysis of all results from published studies as well as our own unpublished data.
methodsWe performed a systematic literature search and meta-analysis of studies investigating the association between prestroke statin use and clinical outcome and included additional data from 126 prestroke statin users and 767 nonusers enrolled at our institution. A total of 12 studies, comprising 2013 statin users and 9682 nonusers, was meta-analyzed using a random effects model. We also meta-analyzed results for individual Trial of ORG 10172 in Acute Stroke Treatment stroke subtypes to determine whether the effect of statin use differed across subtypes using the Breslow-Day test.
resultsMeta-analysis of all available data identified an association between prestroke statin use and improved functional outcome (OR, 1.62; 95% CI, 1.39 to 1.88), but we uncovered evidence of publication bias. The effect of statin use on functional outcome was found to be larger for small vessel strokes compared with other subtypes (Breslow-Day P=0.008).
conclusionsAntecedent use of statins is associated with improved outcome in patients with acute ischemic stroke. This association appears to be stronger in patients with small vessel stroke subtype. However, evidence of publication bias in the existing literature suggests these findings should be interpreted with caution.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.